Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1

R. Rajsbaum; D. Fici; P. A. Fraser; P. O. Flores-Villanueva; Z. L. Awdeh

doi:10.1034/j.1399-0039.2001.580104.x

Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1

R. Rajsbaum, D. Fici, P. A. Fraser, P. O. Flores-Villanueva, Z. L. Awdeh

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The human retinoid X receptor β (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401.

Original language	English (US)
Pages (from-to)	24-29
Number of pages	6
Journal	Tissue Antigens
Volume	58
Issue number	1
DOIs	https://doi.org/10.1034/j.1399-0039.2001.580104.x
State	Published - 2001
Externally published	Yes

Keywords

HLA
HLA-DPB1
Linkage disequilibrium
PCR-RFLP
Polymorphism
RXRB
Retinoic acid receptor

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1034/j.1399-0039.2001.580104.x

Cite this

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title = "Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1",

abstract = "The human retinoid X receptor β (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401.",

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AU - Rajsbaum, R.

AU - Fici, D.

AU - Fraser, P. A.

AU - Flores-Villanueva, P. O.

AU - Awdeh, Z. L.

PY - 2001

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AB - The human retinoid X receptor β (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401.

KW - HLA

KW - HLA-DPB1

KW - Linkage disequilibrium

KW - PCR-RFLP

KW - Polymorphism

KW - RXRB

KW - Retinoic acid receptor

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Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1

Abstract

Keywords

ASJC Scopus subject areas

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