Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1

R. Rajsbaum, D. Fici, P. A. Fraser, P. O. Flores-Villanueva, Z. L. Awdeh

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The human retinoid X receptor β (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalTissue Antigens
Volume58
Issue number1
DOIs
StatePublished - 2001

Keywords

  • HLA
  • HLA-DPB1
  • Linkage disequilibrium
  • PCR-RFLP
  • Polymorphism
  • RXRB
  • Retinoic acid receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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