Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1

Ricardo Rajsbaum Gorodezky, D. Fici, P. A. Fraser, P. O. Flores-Villanueva, Z. L. Awdeh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The human retinoid X receptor β (RXRB) gene is localized in the major histocompatibility complex (MHC) region between DPB1 and RING2. The RXRB gene sequence reported by different investigators suggests that the gene may be polymorphic. In this study, we confirmed one polymorphism by sequencing genomic DNA from four Caucasian individuals. We also developed a restriction fragment length polymorphism (RFLP) analysis to detect this specific polymorphism. Linkage analysis studies between RXRB alleles and a number of HLA markers showed significant linkage disequilibrium between RXRB*T and HLA-DPB1*0401.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalTissue Antigens
Volume58
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Retinoid X Receptors
Linkage Disequilibrium
Genes
Major Histocompatibility Complex
DNA Sequence Analysis
Restriction Fragment Length Polymorphisms
Alleles
Research Personnel
HLA-DPB1 antigen

Keywords

  • HLA
  • HLA-DPB1
  • Linkage disequilibrium
  • PCR-RFLP
  • Polymorphism
  • Retinoic acid receptor
  • RXRB

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1. / Rajsbaum Gorodezky, Ricardo; Fici, D.; Fraser, P. A.; Flores-Villanueva, P. O.; Awdeh, Z. L.

In: Tissue Antigens, Vol. 58, No. 1, 2001, p. 24-29.

Research output: Contribution to journalArticle

Rajsbaum Gorodezky, Ricardo ; Fici, D. ; Fraser, P. A. ; Flores-Villanueva, P. O. ; Awdeh, Z. L. / Polymorphism of the human retinoid X receptor β and linkage disequilibrium with HLA-DPB1. In: Tissue Antigens. 2001 ; Vol. 58, No. 1. pp. 24-29.
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