Polymorphisms of immunity genes and susceptibility to otitis media in children

Johanna Nokso-Koivisto, Tasnee Chonmaitree, Kristofer Jennings, Reuben Matalon, Stan Block, Janak Patel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Acute otitis media (OM) is a common disease which often develops through complex interactions between the host, the pathogen and environmental factors. We studied single nucleotide polymorphisms (SNPs) of genes involved in innate and adaptive immunity, and other host and environmental factors for their role in OM. Methods: Using Sequenom Massarray platform, 21 SNPs were studied in 653 children from prospective (n = 202) and retrospective (n = 451) cohorts. Data were analyzed for the relationship between SNPs and upper respiratory infection (URI) frequency, risk of acute OM during URI episodes, and proneness to recurrent OM. Results: Increased risk for OM proneness was associated with CX3CR1 (Thr280Met) SNP and with a jointly interactive group of IL-10 (21082) SNP, IL-1β (-511) wild type genotype and white race. Family history of OM proneness independently increased the risk for frequent URIs, OM occurrence during URI, and OM proneness. Additionally, IL-1β (231) SNP was associated with increased risk for frequent URIs, but IL-10 (-592), IL-1β (2511), IL-5 (2746) and IL-8 (2251) SNPs were associated with decreased risk of URI. Conclusion: IL-1β (231), CX3CR1 (Thr280Met), IL-10 ( 21082) and IL-1β (2511) SNPs were associated with increased risk for frequent URIs or OM proneness.

Original languageEnglish (US)
Article numbere93930
JournalPLoS One
Volume9
Issue number4
DOIs
StatePublished - Apr 9 2014

Fingerprint

otitis media
Otitis Media
Polymorphism
Immunity
single nucleotide polymorphism
Single Nucleotide Polymorphism
Nucleotides
Genes
immunity
genetic polymorphism
Interleukin-1
interleukin-1
Respiratory Tract Infections
genes
Interleukin-10
interleukin-10
infection
Host-Pathogen Interactions
interleukin-5
Interleukin-5

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Polymorphisms of immunity genes and susceptibility to otitis media in children. / Nokso-Koivisto, Johanna; Chonmaitree, Tasnee; Jennings, Kristofer; Matalon, Reuben; Block, Stan; Patel, Janak.

In: PLoS One, Vol. 9, No. 4, e93930, 09.04.2014.

Research output: Contribution to journalArticle

Nokso-Koivisto, Johanna ; Chonmaitree, Tasnee ; Jennings, Kristofer ; Matalon, Reuben ; Block, Stan ; Patel, Janak. / Polymorphisms of immunity genes and susceptibility to otitis media in children. In: PLoS One. 2014 ; Vol. 9, No. 4.
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