Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research

Yosuke Niimi, Satoshi Fukuda, Suzan Alharbi, Donald S. Prough, Perenlei Enkhbaatar

Research output: Contribution to journalLetter

Abstract

The availability of clinical-relevant large animal models for research in wound healing study is limited. Although a few reports described the wound dressing fixation method using polyurethane foam in patients, no animal studies were conducted to investigate efficacy of the polyurethane foam in grafted burn wounds. In the present study, we report a simple fixation method of grafted burned skin using polyurethane foam dressing (Allevyn Non-Adhesive, smith & nephew, UK) in a clinically relevant ovine grafted burn wound model. The dressing was removed at postoperative day 7 after skin graft. The grafted skin was completely engrafted without any complications. This method was safe and easy to perform and associated with good engraftment without any complications. We believe that the polyurethane foam fixation method may be successfully used in clinical practice as well as in preclinical studies for grafted burn wound repair and regeneration research.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalRegenerative Therapy
Volume14
DOIs
StatePublished - Jun 2020

Keywords

  • Allogenous skin graft
  • Autologous skin graft
  • Burn wound healing
  • Non-adhesive hydrocellular foam dressing
  • Polyurethane foam
  • Sheep

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Developmental Biology

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