Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

Kelly A. Fitzpatrick, Eleanor R. Deardorff, Kendra Pesko, Doug E. Brackney, Bo Zhang, Edward Bedrick, Pei-Yong Shi, Gregory D. Ebel

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

West Nile virus is similar to most other RNA viruses in that it exists in nature as a genetically diverse population. However, the role of this genetic diversity within natural transmission cycles and its importance to virus perpetuation remain poorly understood. Therefore, we determined whether highly genetically diverse populations are more fit compared to less genetically diverse WNV populations. Specifically, we generated three WNV populations that varied in their genetic diversity and evaluated their fitness relative to genetically marked control WNV in vivo in Culex quinquefasciatus mosquitoes and chickens. Our results demonstrate that high genetic diversity leads to fitness gains in vector mosquitoes, but not chickens.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalVirology
Volume404
Issue number1
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

West Nile virus
Culicidae
Population
Chickens
Culex
RNA Viruses
Viruses

Keywords

  • Arbovirus
  • Fitness
  • Flavivirus
  • Mosquitoes
  • Quasispecies
  • West Nile virus

ASJC Scopus subject areas

  • Virology

Cite this

Fitzpatrick, K. A., Deardorff, E. R., Pesko, K., Brackney, D. E., Zhang, B., Bedrick, E., ... Ebel, G. D. (2010). Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes. Virology, 404(1), 89-95. https://doi.org/10.1016/j.virol.2010.04.029

Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes. / Fitzpatrick, Kelly A.; Deardorff, Eleanor R.; Pesko, Kendra; Brackney, Doug E.; Zhang, Bo; Bedrick, Edward; Shi, Pei-Yong; Ebel, Gregory D.

In: Virology, Vol. 404, No. 1, 08.2010, p. 89-95.

Research output: Contribution to journalArticle

Fitzpatrick, KA, Deardorff, ER, Pesko, K, Brackney, DE, Zhang, B, Bedrick, E, Shi, P-Y & Ebel, GD 2010, 'Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes', Virology, vol. 404, no. 1, pp. 89-95. https://doi.org/10.1016/j.virol.2010.04.029
Fitzpatrick KA, Deardorff ER, Pesko K, Brackney DE, Zhang B, Bedrick E et al. Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes. Virology. 2010 Aug;404(1):89-95. https://doi.org/10.1016/j.virol.2010.04.029
Fitzpatrick, Kelly A. ; Deardorff, Eleanor R. ; Pesko, Kendra ; Brackney, Doug E. ; Zhang, Bo ; Bedrick, Edward ; Shi, Pei-Yong ; Ebel, Gregory D. / Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes. In: Virology. 2010 ; Vol. 404, No. 1. pp. 89-95.
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