Population versus customized fetal growth norms and adverse outcomes in an intrapartum cohort

Maged Costantine, Yinglei Lai, Steven L. Bloom, Catherine Y. Spong, Michael W. Varner, Dwight J. Rouse, Susan M. Ramin, Steve N. Caritis, Alan M. Peaceman, Yoram Sorokin, Anthony Sciscione, Brian M. Mercer, John M. Thorp, Fergal D. Malone, Margaret Harper, Jay D. Iams

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective To compare population versus customized fetal growth norms in identifying neonates at risk for adverse outcomes (APO) associated with small for gestational age (SGA). Study Design Secondary analysis of an intrapartum fetal pulse oximetry trial in nulliparous women at term. Birth weight percentiles were calculated using ethnicity- and gender-specific population norms and customized norms (Gardosi). Results Of the studied neonates, 508 (9.9%) and 584 (11.3%) were SGA by population (SGApop) and customized (SGAcust) norms, respectively. SGApop infants were significantly associated with a composite adverse neonatal outcome, neonatal intensive care admission, low fetal oxygen saturation, and reduced risk of cesarean delivery; both SGApop and SGAcust infants were associated with a 5-minute Apgar score < 4. The ability of customized and population birth weight percentiles in predicting APO was poor (12 of 14 APOs had area under the curve of <0.6). Conclusion In this intrapartum cohort, neither customized nor normalized population norms adequately identified neonates at risk of APO related to SGA.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalAmerican Journal of Perinatology
Volume30
Issue number4
DOIs
StatePublished - 2013

Fingerprint

Fetal Development
Population
Gestational Age
Newborn Infant
Birth Weight
Neonatal Intensive Care
Oximetry
Apgar Score
Area Under Curve
Oxygen

Keywords

  • adverse outcomes
  • customized norm
  • fetal growth
  • small for gestational age

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Costantine, M., Lai, Y., Bloom, S. L., Spong, C. Y., Varner, M. W., Rouse, D. J., ... Iams, J. D. (2013). Population versus customized fetal growth norms and adverse outcomes in an intrapartum cohort. American Journal of Perinatology, 30(4), 335-341. https://doi.org/10.1055/s-0032-1324708

Population versus customized fetal growth norms and adverse outcomes in an intrapartum cohort. / Costantine, Maged; Lai, Yinglei; Bloom, Steven L.; Spong, Catherine Y.; Varner, Michael W.; Rouse, Dwight J.; Ramin, Susan M.; Caritis, Steve N.; Peaceman, Alan M.; Sorokin, Yoram; Sciscione, Anthony; Mercer, Brian M.; Thorp, John M.; Malone, Fergal D.; Harper, Margaret; Iams, Jay D.

In: American Journal of Perinatology, Vol. 30, No. 4, 2013, p. 335-341.

Research output: Contribution to journalArticle

Costantine, M, Lai, Y, Bloom, SL, Spong, CY, Varner, MW, Rouse, DJ, Ramin, SM, Caritis, SN, Peaceman, AM, Sorokin, Y, Sciscione, A, Mercer, BM, Thorp, JM, Malone, FD, Harper, M & Iams, JD 2013, 'Population versus customized fetal growth norms and adverse outcomes in an intrapartum cohort', American Journal of Perinatology, vol. 30, no. 4, pp. 335-341. https://doi.org/10.1055/s-0032-1324708
Costantine, Maged ; Lai, Yinglei ; Bloom, Steven L. ; Spong, Catherine Y. ; Varner, Michael W. ; Rouse, Dwight J. ; Ramin, Susan M. ; Caritis, Steve N. ; Peaceman, Alan M. ; Sorokin, Yoram ; Sciscione, Anthony ; Mercer, Brian M. ; Thorp, John M. ; Malone, Fergal D. ; Harper, Margaret ; Iams, Jay D. / Population versus customized fetal growth norms and adverse outcomes in an intrapartum cohort. In: American Journal of Perinatology. 2013 ; Vol. 30, No. 4. pp. 335-341.
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