Positional assignment of differentially substituted bisaminoacylated pdCpAs

David J. Maloney; Noha Ghanem; Jia Zhou; Sidney M. Hecht

doi:10.1039/b708786a

Positional assignment of differentially substituted bisaminoacylated pdCpAs

David J. Maloney, Noha Ghanem, Jia Zhou, Sidney M. Hecht

Pharmacology & Toxicology

Research output: Contribution to journal › Article

4 Scopus citations

Abstract

The synthesis and NMR analysis of a 2′-O-alanyl, 3′-O-[1- ¹³C]valyl-pdCpA derivative has permitted the definitive assignment of the positions of acylation of tandemly activated pdCpAs, and the bisaminoacylated transfer RNAs derived therefrom.

Original language	English (US)
Pages (from-to)	3135-3138
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	5
Issue number	19
DOIs	https://doi.org/10.1039/b708786a
State	Published - 2007

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Positional assignment of differentially substituted bisaminoacylated pdCpAs",

abstract = "The synthesis and NMR analysis of a 2′-O-alanyl, 3′-O-[1- 13C]valyl-pdCpA derivative has permitted the definitive assignment of the positions of acylation of tandemly activated pdCpAs, and the bisaminoacylated transfer RNAs derived therefrom.",

author = "Maloney, {David J.} and Noha Ghanem and Jia Zhou and Hecht, {Sidney M.}",

year = "2007",

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AU - Ghanem, Noha

AU - Zhou, Jia

AU - Hecht, Sidney M.

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AB - The synthesis and NMR analysis of a 2′-O-alanyl, 3′-O-[1- 13C]valyl-pdCpA derivative has permitted the definitive assignment of the positions of acylation of tandemly activated pdCpAs, and the bisaminoacylated transfer RNAs derived therefrom.

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JO - Organic and Biomolecular Chemistry

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