Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection

Veljko Veljkovic, Slobodan Paessler

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

Abstract

The in silico analysis shows that the envelope glycoproteins E of Zika viruses (ZIKV) isolated in Asia, Africa and South and Central America encode highly conserved information determining their interacting profile and immunological properties. Previously it was shown that the same information is encoded in the primary structure of the hemagglutinin subunit 1 (HA1) from pdmH1N1 influenza A virus. This similarity suggests possible repurposing of the seasonal influenza vaccine containing pdmH1N1 component for prevention of the ZIKV infection.

Original languageEnglish (US)
Article number190
JournalF1000Research
Volume5
DOIs
StatePublished - 2016

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Central America
South America
Influenza Vaccines
Influenza A virus
Viruses
Computer Simulation
Glycoproteins
Hemagglutinins
Zika Virus Infection
Zika Virus
hemagglutinin I

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Possible repurposing of seasonal influenza vaccine for prevention of Zika virus infection. / Veljkovic, Veljko; Paessler, Slobodan.

In: F1000Research, Vol. 5, 190, 2016.

Research output: Contribution to journalComment/debate

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