Post-exposure therapy of filovirus infections

Gary Wong, Xiangguo Qiu, Gene G. Olinger, Gary P. Kobinger

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Filovirus infections cause fatal hemorrhagic fever characterized by the initial onset of general symptoms before rapid progression to severe disease; the most virulent species can cause death to susceptible hosts within 10 days after the appearance of symptoms. Before the advent of monoclonal antibody (mAb) therapy, infection of nonhuman primates (NHPs) with the most virulent filovirus species was fatal if interventions were not administered within minutes. A novel nucleoside analogue, BCX4430, has since been shown to also demonstrate protective efficacy with a delayed treatment start. This review summarizes and evaluates the potential of current experimental candidates for treating filovirus disease with regard to their feasibility and use in the clinic, and assesses the most promising strategies towards the future development of a pan-filovirus medical countermeasure.

Original languageEnglish (US)
Pages (from-to)456-463
Number of pages8
JournalTrends in Microbiology
Volume22
Issue number8
DOIs
StatePublished - Aug 2014
Externally publishedYes

Keywords

  • Ebola
  • Filovirus
  • Immunotherapy
  • Marburg
  • Monoclonal antibodies
  • Post-exposure

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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