Post injury hypermetabolic response and magnitude of translocation: Prevention by early enteral nutrition

L. Gianotti, J. L. Nelson, J. W. Alexander, C. L. Chalk, Tonyia Eaves-Pyles

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

The relationship between hypermetabolism and bacterial translocation was investigated in guinea pigs receiving a 40% burn. Animals were infused intragastrically with a complete enteral diet or Ringer's solution for 48 h, given 1010 14C-labeled Escherichia coli intragastrically, and killed 4 h later. Resting metabolic expenditure (RME), translocation (dpm of the 14C- labeled E. coli) to the portal blood and ileal mucosa, plasma cortisol, and urinary vanillylmandelic acid (VMA) were determined. Enterally fed animals had significantly lower RME, cortisol, VMA, and dpm, but higher mucosal and body weight than the Ringer's group. Disintegrations per minute (dpm) in the blood were positively correlated with RME (r = 0.856), cortisol (r = 0.872), VMA (r = 0.759), and dpm mucosa (r = 0.836) and inversely correlated with mucosal weight (r = -0.883). We conclude that bacterial translocation is reduced by early feeding and is an important cause of hypermetabolism and stress hormone production after burn injury.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalNutrition
Volume10
Issue number3
StatePublished - 1994
Externally publishedYes

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Keywords

  • bacterial translocation
  • burn injury
  • catabolism
  • enteral nutrition
  • Escherichia coli
  • hormone
  • hypermetabolism
  • intestinal function

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Surgery

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