@inbook{9cf0c8db9bba40c7a1c00e4875b437cf,
title = "Post-translational Modifications in the Human Proteome",
abstract = "The Chromosome-Centric Human Proteome Project (C-HPP) is a global project aimed to identify at least one protein isoform encoded by the approximately 20, 300 human genes. In addition, protein post-translational modifications will be characterized, with the initial goal of detecting phosphorylation, acetylation, and glycosylation sites in each protein. In this chapter, we provide an overview of known post-translational modifications, their known biological functions, and present strategies to detect them on both a single protein and proteomic scales. In future proteomic studies, global characterization of post-translation modifications, splice variants, and variants caused by single nucleotide polymorphisms (SNPs) will be necessary to fully understand the role of proteins in human biology and disease.",
keywords = "Acetylation, C-HPP, Glycosylation, Mass spectrometry, Phosphorylation, Post-translational modification, Proteomics, Ubiquitination",
author = "Cheryl Lichti and Wildburger, {Norelle C.} and Emmett, {Mark R.} and Ekaterina Mostovenko and Shavkunov, {Alexander S.} and Strain, {Shinji K.} and Carol Nilsson",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media Dordrecht 2014.",
year = "2014",
doi = "10.1007/978-94-017-9202-8_6",
language = "English (US)",
series = "Translational Bioinformatics",
publisher = "Springer Nature",
pages = "101--136",
booktitle = "Translational Bioinformatics",
address = "United States",
}