Post-traumatic hypopituitarism and fatigue

Brent E. Masel, Dennis J. Zgaljardic, Jack Forman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Post-traumatic hypopituitarism (PTH) associated with chronic cognitive, psychiatric, and/or behavioural sequelae is common following moderate to severe traumatic brain injury (TBI). More specifically, due to a cascade of hormonal deficiencies secondary to PTH, individuals with TBI may experience debilitating fatigue that can negatively impact functional recovery, as it can limit participation in brain injury rehabilitation services and lead to an increase in maladaptive lifestyle practices. While the mechanisms underlying fatigue and TBI are not entirely understood, the current review will address the specific anatomy and physiology of the pituitary gland, as well as the association between pituitary dysfunction and fatigue in individuals with TBI.

Original languageEnglish (US)
Pages (from-to)1071-1079
Number of pages9
JournalNeuropsychological Rehabilitation
Issue number7
StatePublished - Oct 3 2017
Externally publishedYes


  • Fatigue
  • Hormones
  • Pituitary

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Rehabilitation
  • Applied Psychology


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