Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation

R. Tokyay, S. T. Zeigler, D. L. Traber, J. C. Stothert, H. M. Loick, J. P. Heggers, David Herndon

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Splanchnic ischemia has been associated with bacterial translocation and increased endotoxin absorption from the gut. To study the effects of major burn on splanchnic circulation, minipigs were randomized to receive 40% flame burn and Parkland resuscitation or sham burn and maintenance fluids. Total and fractionated blood flow, O2 delivery and consumption, mucosal pH of the intestine, and endotoxin levels in the superior mesenteric vein were measured for 48 h, and then abdominal organs were harvested for bacteriological culture and histopathological analysis. Total mesenteric blood flow and fractionated blood flow to the mucosa-submucosa of the jejunum, cecum, and colon decreased 2 and 4 h postburn. Although mesenteric O2 consumption was unchanged, mesenteric O2 delivery and intestinal mucosal pH were decreased during the early postburn period. Concomitantly, endotoxin levels in the superior mesenteric vein were significantly elevated during the first 8 h postburn. The bacteriological cultures of the systemic tissue samples showed increased bacteria translocation in the burn group. After major burns, there is a transient selective splanchnic vasoconstriction, which is associated with intestinal mucosal acidosis and increased incidence of bacterial translocation and endotoxin absorption from the gut.

Original languageEnglish (US)
Pages (from-to)1521-1527
Number of pages7
JournalJournal of Applied Physiology
Volume74
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Bacterial Translocation
Vasoconstriction
Endotoxins
Mesenteric Veins
Viscera
Splanchnic Circulation
Miniature Swine
Cecum
Jejunum
Acidosis
Burns
Resuscitation
Intestines
Colon
Mucous Membrane
Ischemia
Maintenance
Bacteria
Incidence
Gastrointestinal Absorption

Keywords

  • blood flow
  • burns
  • mesenteric
  • microspheres
  • oxygen consumption
  • oxygen delivery
  • splanchnic
  • tonometer

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Tokyay, R., Zeigler, S. T., Traber, D. L., Stothert, J. C., Loick, H. M., Heggers, J. P., & Herndon, D. (1993). Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation. Journal of Applied Physiology, 74(4), 1521-1527.

Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation. / Tokyay, R.; Zeigler, S. T.; Traber, D. L.; Stothert, J. C.; Loick, H. M.; Heggers, J. P.; Herndon, David.

In: Journal of Applied Physiology, Vol. 74, No. 4, 1993, p. 1521-1527.

Research output: Contribution to journalArticle

Tokyay, R, Zeigler, ST, Traber, DL, Stothert, JC, Loick, HM, Heggers, JP & Herndon, D 1993, 'Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation', Journal of Applied Physiology, vol. 74, no. 4, pp. 1521-1527.
Tokyay R, Zeigler ST, Traber DL, Stothert JC, Loick HM, Heggers JP et al. Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation. Journal of Applied Physiology. 1993;74(4):1521-1527.
Tokyay, R. ; Zeigler, S. T. ; Traber, D. L. ; Stothert, J. C. ; Loick, H. M. ; Heggers, J. P. ; Herndon, David. / Postburn gastrointestinal vasoconstriction increases bacterial and endotoxin translocation. In: Journal of Applied Physiology. 1993 ; Vol. 74, No. 4. pp. 1521-1527.
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