Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs

J. Hansbrough, V. Peterson, H. N. Claman, Ramon Zapata Sirvent

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalSurgery
Volume95
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Cellular Immunity
Immunosuppression
Animal Models
Pharmaceutical Preparations
Dinitrofluorobenzene
Ibuprofen
Alkylating Agents
Cytotoxins
Wounds and Injuries
Indomethacin
Cyclophosphamide
Anti-Inflammatory Agents
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Surgery

Cite this

Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs. / Hansbrough, J.; Peterson, V.; Claman, H. N.; Zapata Sirvent, Ramon.

In: Surgery, Vol. 95, No. 3, 01.01.1984, p. 290-296.

Research output: Contribution to journalArticle

@article{40d3cbe6a4924f65a3614dfbc01b48c2,
title = "Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs",
abstract = "We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.",
author = "J. Hansbrough and V. Peterson and Claman, {H. N.} and {Zapata Sirvent}, Ramon",
year = "1984",
month = "1",
day = "1",
language = "English (US)",
volume = "95",
pages = "290--296",
journal = "Surgery (United States)",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs

AU - Hansbrough, J.

AU - Peterson, V.

AU - Claman, H. N.

AU - Zapata Sirvent, Ramon

PY - 1984/1/1

Y1 - 1984/1/1

N2 - We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.

AB - We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.

UR - http://www.scopus.com/inward/record.url?scp=0021348622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021348622&partnerID=8YFLogxK

M3 - Article

C2 - 6322373

AN - SCOPUS:0021348622

VL - 95

SP - 290

EP - 296

JO - Surgery (United States)

JF - Surgery (United States)

SN - 0039-6060

IS - 3

ER -