Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs

J. Hansbrough, V. Peterson, H. N. Claman, Ramon Zapata Sirvent

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalSurgery
Volume95
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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