Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase

Blake Rasmussen, C. R. Hancock, W. W. Winder

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Previous studies have demonstrated that oxygen consumption and fat oxidation remain elevated in the postexercise period. The purpose of this study was to determine whether malonyl-CoA, an inhibitor of fatty acid oxidation, remains depressed in muscle after exercise. Rats were sprinted for 5 min (40 m/min, 5% grade) or run for 30 min (21 m/min, 15% grade). Red quadriceps malonyl-CoA returned to resting values by 90 min postexercise in the sprinting rats and remained significantly lower at least 90 min postexercise in the 30-min exercise group. AMP-activated protein kinase activity remained significantly elevated (P < 0.05) for 10 min after exercise in both groups. The most rapid rate of glycogen repletion was in the first 30 min postexercise. The respiratory exchange ratio decreased from a nonexercise value of 0.87 ± 0.01 to an average 0.82 ± 0.01 during the 90-min period after 30 min of exercise. Thus muscle malonyl-CoA remains depressed and fat oxidation is elevated for relatively prolonged periods after a single bout of exercise. This may allow fat oxidation to contribute more to muscle energy requirements, thus leaving more glucose for replenishment of muscle glycogen.

Original languageEnglish (US)
Pages (from-to)1629-1634
Number of pages6
JournalJournal of Applied Physiology
Volume85
Issue number5
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Malonyl Coenzyme A
Acetyl-CoA Carboxylase
AMP-Activated Protein Kinases
Skeletal Muscle
Muscles
Fats
Glycogen
Oxygen Consumption
Fatty Acids
Glucose
acetyl adenylate

Keywords

  • Carnitine palmitoyl transferase-1
  • Postexercise substrate utilization

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase. / Rasmussen, Blake; Hancock, C. R.; Winder, W. W.

In: Journal of Applied Physiology, Vol. 85, No. 5, 11.1998, p. 1629-1634.

Research output: Contribution to journalArticle

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