Postoperative upper and lower gastrointestinal recovery and gastrointestinal morbidity in patients undergoing bowel resection: Pooled analysis of placebo data from 3 randomized controlled trials

Conor P. Delaney, Anthony J. Senagore, Eugene R. Viscusi, Bruce G. Wolff, John Fort, Wei Du, Lee Techner, Bruce Wallin

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Background: This analysis examines gastrointestinal recovery in patients who underwent bowel resection (BR) in 3 recent trials. Methods: Patients who underwent BR in the placebo groups of 3 randomized, double-blind, phase III, parallel-group, multicenter alvimopan efficacy trials were analyzed. Results: Most patients tolerated solid food and had a bowel movement by postoperative day 4. The majority of patients were discharged from the hospital by day 6, but 24.4% required a prolonged hospital stay or readmission. The incidence of nausea was highest on the day of surgery and decreased thereafter, whereas vomiting was uncommon on the day of surgery but increased slightly on postoperative days 1 to 6. The incidence of postoperative nasogastric tube insertion was highest (12%) on day 2. Conclusions: This analysis provides valuable clinical insight into gastrointestinal recovery after BR in a large homogenous patient population receiving multimodal care.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalAmerican Journal of Surgery
Volume191
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

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Keywords

  • Alvimopan
  • Bowel resection
  • Hospital discharge
  • Nausea
  • Postoperative ileus
  • Vomiting

ASJC Scopus subject areas

  • Surgery

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