Postprandial motor activity and its relationship to transit in the canine ileum

Christopher P. Johnson, Sushil K. Sarna, Radwan Baytiyeh, Yong Ran Zhu, Verne E. Cowles, Gordon L. Telford, Allan M. Roza, Mark B. Adams

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background. The purpose of this study was to elucidate the mechanism of reduced intestinal transit rate in the ileum as compared with the jejunum. Methods. Twenty-one dogs were each instrumented with 12 strain gauge transducer, 2 collection cannulas, and an infusion catheter defining a 100 cm study in the midjejunum (n = 11) and midileum (n = 10). Postprandial motor activity and intestinal transit were measured 1 hour after ingestion of a 650 kcal solid meal. Contractile activity was analyzed by means of computer programs that determine frequency, amplitude, and propagation behavior of circular smooth muscle contractions. Results. Postprandial ileal contractions occurred with frequency (13.7 ± 2.5 versus 11.5 ± 0.4; p = 0.04) and displayed a higher incidence of propagation (61% ± 2% versus 44% ± 3%; p = 0.0001) than jejunal contractions, but traveled at significantly slower rates (1.0 ± 0.7 cm/sec vs 3.7 ± 0.9 cm/sec; p = 0.0001). The net result was significantly slower transit in the ileum compared with the jejunum (4.7 ± 0.7 cm/min versus 13.1 ± 1.5 cm/min; p = 0.0006). Within each region, transit correlated with parameters of propagating contractions. Stepwise regression of the combined data revealed that contraction velocity was the mst important variable determining intestinal transit rate (r = 0.64; p < 0.001). Conclusions. Contrary to previous thinking, postprandial ileal contractions display a high degree of temporal and spatial organization. Slow ileal transit is mainly due to reduced propagation velocity, which is intrinsic to the circular smooth muscle.

Original languageEnglish (US)
Pages (from-to)182-189
Number of pages8
JournalSurgery
Volume121
Issue number2
DOIs
StatePublished - Feb 1997
Externally publishedYes

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Jejunum
Ileum
Smooth Muscle
Canidae
Motor Activity
Muscle Contraction
Transducers
Meals
Software
Catheters
Eating
Dogs
Incidence
Cannula
Thinking

ASJC Scopus subject areas

  • Surgery

Cite this

Johnson, C. P., Sarna, S. K., Baytiyeh, R., Zhu, Y. R., Cowles, V. E., Telford, G. L., ... Adams, M. B. (1997). Postprandial motor activity and its relationship to transit in the canine ileum. Surgery, 121(2), 182-189. https://doi.org/10.1016/S0039-6060(97)90288-9

Postprandial motor activity and its relationship to transit in the canine ileum. / Johnson, Christopher P.; Sarna, Sushil K.; Baytiyeh, Radwan; Zhu, Yong Ran; Cowles, Verne E.; Telford, Gordon L.; Roza, Allan M.; Adams, Mark B.

In: Surgery, Vol. 121, No. 2, 02.1997, p. 182-189.

Research output: Contribution to journalArticle

Johnson, CP, Sarna, SK, Baytiyeh, R, Zhu, YR, Cowles, VE, Telford, GL, Roza, AM & Adams, MB 1997, 'Postprandial motor activity and its relationship to transit in the canine ileum', Surgery, vol. 121, no. 2, pp. 182-189. https://doi.org/10.1016/S0039-6060(97)90288-9
Johnson CP, Sarna SK, Baytiyeh R, Zhu YR, Cowles VE, Telford GL et al. Postprandial motor activity and its relationship to transit in the canine ileum. Surgery. 1997 Feb;121(2):182-189. https://doi.org/10.1016/S0039-6060(97)90288-9
Johnson, Christopher P. ; Sarna, Sushil K. ; Baytiyeh, Radwan ; Zhu, Yong Ran ; Cowles, Verne E. ; Telford, Gordon L. ; Roza, Allan M. ; Adams, Mark B. / Postprandial motor activity and its relationship to transit in the canine ileum. In: Surgery. 1997 ; Vol. 121, No. 2. pp. 182-189.
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abstract = "Background. The purpose of this study was to elucidate the mechanism of reduced intestinal transit rate in the ileum as compared with the jejunum. Methods. Twenty-one dogs were each instrumented with 12 strain gauge transducer, 2 collection cannulas, and an infusion catheter defining a 100 cm study in the midjejunum (n = 11) and midileum (n = 10). Postprandial motor activity and intestinal transit were measured 1 hour after ingestion of a 650 kcal solid meal. Contractile activity was analyzed by means of computer programs that determine frequency, amplitude, and propagation behavior of circular smooth muscle contractions. Results. Postprandial ileal contractions occurred with frequency (13.7 ± 2.5 versus 11.5 ± 0.4; p = 0.04) and displayed a higher incidence of propagation (61{\%} ± 2{\%} versus 44{\%} ± 3{\%}; p = 0.0001) than jejunal contractions, but traveled at significantly slower rates (1.0 ± 0.7 cm/sec vs 3.7 ± 0.9 cm/sec; p = 0.0001). The net result was significantly slower transit in the ileum compared with the jejunum (4.7 ± 0.7 cm/min versus 13.1 ± 1.5 cm/min; p = 0.0006). Within each region, transit correlated with parameters of propagating contractions. Stepwise regression of the combined data revealed that contraction velocity was the mst important variable determining intestinal transit rate (r = 0.64; p < 0.001). Conclusions. Contrary to previous thinking, postprandial ileal contractions display a high degree of temporal and spatial organization. Slow ileal transit is mainly due to reduced propagation velocity, which is intrinsic to the circular smooth muscle.",
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