Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients

O. B. Holland

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In the past, potassium depletion in both non-digitalised patients and in patients without cardiac disease was thought to cause no adverse cardiac effects. However, several studies have now demonstrated a significant incidence of ventricular ectopic activity (VEA) with diuretic-induced hypokalaemia, even in hypertensive patients without overt heart disease. Additional evidence suggests that sudden death may occasionally result from this VEA. Potassium repletion with potassium-sparing diuretics or with potassium chloride supplementation has generally demonstrated a beneficial therapeutic effect in reducing VEA. However, after diuretic therapy occasional patients may have persistent VEA which may result from focal myocardial lesions associated with potassium depletion. In contrast, diuretic therapy in which normokalaemia is maintained has only been associated with a very low occurrence of VEA. Thus, with the preservation of normokalaemia, diuretic therapy for hypertension does not appear to be associated with the significant hazards of VEA.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalDrugs
Volume31
Issue numberSUPPL. 4
StatePublished - 1986

Fingerprint

Sudden Death
Diuretics
Potassium
Heart Diseases
Potassium Sparing Diuretics
Potassium Chloride
Hypokalemia
Therapeutic Uses
Hazards
Therapeutics
Hypertension
Incidence

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients. / Holland, O. B.

In: Drugs, Vol. 31, No. SUPPL. 4, 1986, p. 78-84.

Research output: Contribution to journalArticle

@article{4eacea6300c44eb6be22e81ab0162701,
title = "Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients",
abstract = "In the past, potassium depletion in both non-digitalised patients and in patients without cardiac disease was thought to cause no adverse cardiac effects. However, several studies have now demonstrated a significant incidence of ventricular ectopic activity (VEA) with diuretic-induced hypokalaemia, even in hypertensive patients without overt heart disease. Additional evidence suggests that sudden death may occasionally result from this VEA. Potassium repletion with potassium-sparing diuretics or with potassium chloride supplementation has generally demonstrated a beneficial therapeutic effect in reducing VEA. However, after diuretic therapy occasional patients may have persistent VEA which may result from focal myocardial lesions associated with potassium depletion. In contrast, diuretic therapy in which normokalaemia is maintained has only been associated with a very low occurrence of VEA. Thus, with the preservation of normokalaemia, diuretic therapy for hypertension does not appear to be associated with the significant hazards of VEA.",
author = "Holland, {O. B.}",
year = "1986",
language = "English (US)",
volume = "31",
pages = "78--84",
journal = "Drugs",
issn = "0012-6667",
publisher = "Adis International Ltd",
number = "SUPPL. 4",

}

TY - JOUR

T1 - Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients

AU - Holland, O. B.

PY - 1986

Y1 - 1986

N2 - In the past, potassium depletion in both non-digitalised patients and in patients without cardiac disease was thought to cause no adverse cardiac effects. However, several studies have now demonstrated a significant incidence of ventricular ectopic activity (VEA) with diuretic-induced hypokalaemia, even in hypertensive patients without overt heart disease. Additional evidence suggests that sudden death may occasionally result from this VEA. Potassium repletion with potassium-sparing diuretics or with potassium chloride supplementation has generally demonstrated a beneficial therapeutic effect in reducing VEA. However, after diuretic therapy occasional patients may have persistent VEA which may result from focal myocardial lesions associated with potassium depletion. In contrast, diuretic therapy in which normokalaemia is maintained has only been associated with a very low occurrence of VEA. Thus, with the preservation of normokalaemia, diuretic therapy for hypertension does not appear to be associated with the significant hazards of VEA.

AB - In the past, potassium depletion in both non-digitalised patients and in patients without cardiac disease was thought to cause no adverse cardiac effects. However, several studies have now demonstrated a significant incidence of ventricular ectopic activity (VEA) with diuretic-induced hypokalaemia, even in hypertensive patients without overt heart disease. Additional evidence suggests that sudden death may occasionally result from this VEA. Potassium repletion with potassium-sparing diuretics or with potassium chloride supplementation has generally demonstrated a beneficial therapeutic effect in reducing VEA. However, after diuretic therapy occasional patients may have persistent VEA which may result from focal myocardial lesions associated with potassium depletion. In contrast, diuretic therapy in which normokalaemia is maintained has only been associated with a very low occurrence of VEA. Thus, with the preservation of normokalaemia, diuretic therapy for hypertension does not appear to be associated with the significant hazards of VEA.

UR - http://www.scopus.com/inward/record.url?scp=0022588507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022588507&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 78

EP - 84

JO - Drugs

JF - Drugs

SN - 0012-6667

IS - SUPPL. 4

ER -