Keyphrases
Mechanism of Action
100%
Inhibitory Mechanism
100%
RNA-dependent RNA Polymerase (RdRP)
100%
Dengue Virus
100%
Polymerase Inhibitors
100%
NS5A
100%
Resistance Mechanisms
100%
Resistance Profiling
100%
Flavivirus
50%
Active Sites
25%
Virus RNA
25%
Thumb
25%
Pregenomic RNA (pgRNA)
12%
X-ray Crystallography
12%
Double-stranded RNA
12%
Drug Candidates
12%
Replicon
12%
Conformational Change
12%
Antiretroviral Therapy
12%
RNA Genome
12%
IC50 Value
12%
Genome Sequencing
12%
Amino Acid Variation
12%
Zika Virus
12%
Micromolar Concentration
12%
Enzymatic Activity
12%
Well-ordered
12%
Polymerase Domain
12%
Evolutionary Conservation
12%
Serious Condition
12%
Emerging Pathogen
12%
Dengue Virus Serotype 2
12%
Compound Screening
12%
Exit Tunnel
12%
Initiation Mechanism
12%
Cell Culture Assay
12%
Closed Conformation
12%
Screening Campaign
12%
RNA Polymerase Inhibitor
12%
Fragment Screening
12%
Mixed Inhibition
12%
Inhibition Kinetics
12%
Priming Loop
12%
Allosteric Pocket
12%
Structure-guided
12%
Biochemistry, Genetics and Molecular Biology
Structural Protein
100%
Polymerase
100%
Dengue Virus
100%
RNA-dependent RNA Polymerase
100%
Flavivirus
44%
RNA
33%
Serotype
33%
Active Site
22%
RNA Virus
22%
Crystal Structure
11%
Infectious Agent
11%
Double-Stranded RNA
11%
Cell Culture
11%
Amino Acids
11%
Replicon
11%
Conformational Change
11%
Guanosine Triphosphate
11%
Enzyme Activity
11%
Genome Sequencing
11%
Conformation
11%
Genetic Conservation
11%
X-Ray Crystallography
11%
EC50
11%
Inhibition Kinetics
11%
Zika Virus
11%