Potential application of optical coherence tomography for non-invasive monitoring of glucose concentration

K. Larin, I. Larina, Massoud Motamedi, V. Gelikonov, R. Kuranov, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Scopus citations

Abstract

In the past two decades, the applications of optical monitoring for non-invasive assessment of glucose have been pursued with limited success. We have investigated potential application of optical coherence tomography (OCT) for non-invasive and continuous monitoring of blood glucose concentration. An OCT system with the wavelength of 1300 nm was used in phantom and in vivo studies. Polystyrene spheres with the diameter of 0.76 μm were used as scatterers in aqueous solutions in the phantom studies. We have found 4.5% change of the OCT signal slope as a function of glucose concentration in the range from 0 to 100 mM in the phantoms. This is in good agreement with theoretical calculations performed using Mie's theory. Bolus glucose injection and glucose clamping experiments were performed in New Zealand rabbits and Yucatan micropigs. OCT images were obtained from skin (dorsal area of the pigs and rabbit ear). Our pilot studies show close correlation between actual blood glucose concentration and slope of the OCT signals. The slope decreased substantially (about 40% in tissues in vivo) with the increase of blood glucose concentration from 4 to 30 mM. In conclusion, we have demonstrated that glucose-induced changes in optical properties of skin can be monitored by OCT suggesting that a new OCT-based optical sensor could be developed for sensitive and accurate non-invasive monitoring of glucose concentration in vivo.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.V. Priezzhev, G.L. Cote
Pages83-90
Number of pages8
Volume4263
DOIs
StatePublished - 2001
EventOptical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring - San Jose, CA, United States
Duration: Jan 22 2001Jan 23 2001

Other

OtherOptical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring
CountryUnited States
CitySan Jose, CA
Period1/22/011/23/01

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Keywords

  • Blood glucose
  • Non-invasive
  • OCT

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Larin, K., Larina, I., Motamedi, M., Gelikonov, V., Kuranov, R., & Esenaliev, R. (2001). Potential application of optical coherence tomography for non-invasive monitoring of glucose concentration. In A. V. Priezzhev, & G. L. Cote (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4263, pp. 83-90) https://doi.org/10.1117/12.429342