Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa

Alioune Gaye, Eryu Wang, Nikos Vasilakis, Hilda Guzman, Diawo Diallo, Cheikh Talla, Yamar Ba, Ibrahima Dia, Scott Weaver, Mawlouth Diallo

Research output: Contribution to journalArticle

Abstract

Dengue fever (DEN) is the most common arboviral disease in the world and dengue virus (DENV) causes 390 million annual infections around the world, of which 240 million are inapparent and 96 million are symptomatic. During the past decade a changing epidemiological pattern has been observed in Africa, with DEN outbreaks reported in all regions. In Senegal, all DENV serotypes have been reported. These important changes in the epidemiological profile of DEN are occurring in a context where there is no qualified vaccine against DEN. Further there is significant gap of knowledge on the vector bionomics and transmission dynamics in the African region to effectively prevent and control epidemics. Except for DENV-2, few studies have been performed with serotypes 1, 3, and 4, so this study was undertaken to fill out this gap. We assessed the vector competence of Aedes (Diceromyia) furcifer, Ae. (Diceromyia) taylori, Ae. (Stegomyia) luteocephalus, sylvatic and urban Ae. (Stegomyia) aegypti populations from Senegal for DENV-1, DENV-3 and DENV-4 using experimental oral infection. Whole bodies and wings/legs were tested for DENV presence by cell culture assays and saliva samples were tested by real time RT-PCR to estimate infection, disseminated infection and transmission rates. Our results revealed a low capacity of sylvatic and urban Aedes mosquitoes from Senegal to transmit DENV-1, DENV-3 and DENV-4 and an impact of infection on their mortality. The highest potential transmission rate was 20% despite the high susceptibility and disseminated infection rates up to 93.7% for the 3 Ae. aegypti populations tested, and 84.6% for the sylvatic vectors Ae. furcifer, Ae. taylori and Ae. luteocephalus.

Original languageEnglish (US)
Pages (from-to)e0007043
JournalPLoS neglected tropical diseases
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2019

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Senegal
Dengue Virus
Western Africa
Dengue
Aedes
Culicidae
Infection
Serogroup
Infectious Disease Transmission
Ecology
Saliva
Mental Competency
Population
Disease Outbreaks
Real-Time Polymerase Chain Reaction
Leg
Vaccines
Cell Culture Techniques

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa. / Gaye, Alioune; Wang, Eryu; Vasilakis, Nikos; Guzman, Hilda; Diallo, Diawo; Talla, Cheikh; Ba, Yamar; Dia, Ibrahima; Weaver, Scott; Diallo, Mawlouth.

In: PLoS neglected tropical diseases, Vol. 13, No. 2, 01.02.2019, p. e0007043.

Research output: Contribution to journalArticle

Gaye, Alioune ; Wang, Eryu ; Vasilakis, Nikos ; Guzman, Hilda ; Diallo, Diawo ; Talla, Cheikh ; Ba, Yamar ; Dia, Ibrahima ; Weaver, Scott ; Diallo, Mawlouth. / Potential for sylvatic and urban Aedes mosquitoes from Senegal to transmit the new emerging dengue serotypes 1, 3 and 4 in West Africa. In: PLoS neglected tropical diseases. 2019 ; Vol. 13, No. 2. pp. e0007043.
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