Potential mechanisms and implications for the formation of tau oligomeric strains

Julia E. Gerson, Amrit Mudher, Rakez Kayed

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The culmination of many years of increasing research into the toxicity of tau aggregation in neurodegenerative disease has led to the consensus that soluble, oligomeric forms of tau are likely the most toxic entities in disease. While tauopathies overlap in the presence of tau pathology, each disease has a unique combination of symptoms and pathological features; however, most study into tau has grouped tau oligomers and studied them as a homogenous population. Established evidence from the prion field combined with the most recent tau and amyloidogenic protein research suggests that tau is a prion-like protein, capable of seeding the spread of pathology throughout the brain. Thus, it is likely that tau may also form prion-like strains or diverse conformational structures that may differ by disease and underlie some of the differences in symptoms and pathology in neurodegenerative tauopathies. The development of techniques and new technology for the detection of tau oligomeric strains may, therefore, lead to more efficacious diagnostic and treatment strategies for neurodegenerative disease. (Figure presented.)

Original languageEnglish (US)
Pages (from-to)482-496
Number of pages15
JournalCritical Reviews in Biochemistry and Molecular Biology
Volume51
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Prions
Pathology
Tauopathies
Neurodegenerative diseases
Neurodegenerative Diseases
Amyloidogenic Proteins
tau Proteins
Poisons
Research
Oligomers
Toxicity
Brain
Agglomeration
Technology
Population
Proteins

Keywords

  • aggregation
  • amyloid
  • neurodegeneration
  • oligomer
  • Tau

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Potential mechanisms and implications for the formation of tau oligomeric strains. / Gerson, Julia E.; Mudher, Amrit; Kayed, Rakez.

In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 51, No. 6, 01.11.2016, p. 482-496.

Research output: Contribution to journalReview article

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N2 - The culmination of many years of increasing research into the toxicity of tau aggregation in neurodegenerative disease has led to the consensus that soluble, oligomeric forms of tau are likely the most toxic entities in disease. While tauopathies overlap in the presence of tau pathology, each disease has a unique combination of symptoms and pathological features; however, most study into tau has grouped tau oligomers and studied them as a homogenous population. Established evidence from the prion field combined with the most recent tau and amyloidogenic protein research suggests that tau is a prion-like protein, capable of seeding the spread of pathology throughout the brain. Thus, it is likely that tau may also form prion-like strains or diverse conformational structures that may differ by disease and underlie some of the differences in symptoms and pathology in neurodegenerative tauopathies. The development of techniques and new technology for the detection of tau oligomeric strains may, therefore, lead to more efficacious diagnostic and treatment strategies for neurodegenerative disease. (Figure presented.)

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