Abstract
Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries. Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response. Robust diagnostic tools for neonates jeopardized by infection and inflammation may thus decrease the overall neonatal morbidity substantially. Amniotic fluid retrieved during labor retains fetal and pregnancy-related protein fingerprint and its sampling does not place any unwanted stress on women. Using exploratory and targeted methods we analyzed proteomes of amniotic fluid sampled at the end of spontaneous preterm labor prior to delivery from women with and without infection and inflammation. Exploratory data indicated several amniotic fluid proteins to be associated with infectious-inflammatory complications in spontaneous preterm birth. LC-SRM analysis subsequently verified statistically significant changes in lipocalin-1 (P=0.047 and AUC = 0.67, P=0.046), glycodelin (P=0.013 and AUC = 0.73, P=0.013), and nicotinamide phosphoribosyltransferase (P=0.018 and AUC = 0.71, P=0.01).
| Original language | English (US) |
|---|---|
| Article number | 343501 |
| Journal | BioMed Research International |
| Volume | 2015 |
| DOIs | |
| State | Published - 2015 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
Cite this
Potential peripartum markers of infectious-inflammatory complications in spontaneous preterm birth. / Tambor, Vojtech; Vajrychova, Marie; Kacerovsky, Marian; Link, Marek; Domasinska, Petra; Menon, Ramkumar; Lenco, Juraj.
In: BioMed Research International, Vol. 2015, 343501, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Potential peripartum markers of infectious-inflammatory complications in spontaneous preterm birth
AU - Tambor, Vojtech
AU - Vajrychova, Marie
AU - Kacerovsky, Marian
AU - Link, Marek
AU - Domasinska, Petra
AU - Menon, Ramkumar
AU - Lenco, Juraj
PY - 2015
Y1 - 2015
N2 - Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries. Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response. Robust diagnostic tools for neonates jeopardized by infection and inflammation may thus decrease the overall neonatal morbidity substantially. Amniotic fluid retrieved during labor retains fetal and pregnancy-related protein fingerprint and its sampling does not place any unwanted stress on women. Using exploratory and targeted methods we analyzed proteomes of amniotic fluid sampled at the end of spontaneous preterm labor prior to delivery from women with and without infection and inflammation. Exploratory data indicated several amniotic fluid proteins to be associated with infectious-inflammatory complications in spontaneous preterm birth. LC-SRM analysis subsequently verified statistically significant changes in lipocalin-1 (P=0.047 and AUC = 0.67, P=0.046), glycodelin (P=0.013 and AUC = 0.73, P=0.013), and nicotinamide phosphoribosyltransferase (P=0.018 and AUC = 0.71, P=0.01).
AB - Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries. Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response. Robust diagnostic tools for neonates jeopardized by infection and inflammation may thus decrease the overall neonatal morbidity substantially. Amniotic fluid retrieved during labor retains fetal and pregnancy-related protein fingerprint and its sampling does not place any unwanted stress on women. Using exploratory and targeted methods we analyzed proteomes of amniotic fluid sampled at the end of spontaneous preterm labor prior to delivery from women with and without infection and inflammation. Exploratory data indicated several amniotic fluid proteins to be associated with infectious-inflammatory complications in spontaneous preterm birth. LC-SRM analysis subsequently verified statistically significant changes in lipocalin-1 (P=0.047 and AUC = 0.67, P=0.046), glycodelin (P=0.013 and AUC = 0.73, P=0.013), and nicotinamide phosphoribosyltransferase (P=0.018 and AUC = 0.71, P=0.01).
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U2 - 10.1155/2015/343501
DO - 10.1155/2015/343501
M3 - Article
VL - 2015
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 343501
ER -