Potential peripartum markers of infectious-inflammatory complications in spontaneous preterm birth

Vojtech Tambor, Marie Vajrychova, Marian Kacerovsky, Marek Link, Petra Domasinska, Ramkumar Menon, Juraj Lenco

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Spontaneous preterm birth significantly contributes to the overall neonatal morbidity associated with preterm deliveries. Nearly 50% of cases are associated with microbial invasion of the amniotic cavity followed by an inflammatory response. Robust diagnostic tools for neonates jeopardized by infection and inflammation may thus decrease the overall neonatal morbidity substantially. Amniotic fluid retrieved during labor retains fetal and pregnancy-related protein fingerprint and its sampling does not place any unwanted stress on women. Using exploratory and targeted methods we analyzed proteomes of amniotic fluid sampled at the end of spontaneous preterm labor prior to delivery from women with and without infection and inflammation. Exploratory data indicated several amniotic fluid proteins to be associated with infectious-inflammatory complications in spontaneous preterm birth. LC-SRM analysis subsequently verified statistically significant changes in lipocalin-1 (P=0.047 and AUC = 0.67, P=0.046), glycodelin (P=0.013 and AUC = 0.73, P=0.013), and nicotinamide phosphoribosyltransferase (P=0.018 and AUC = 0.71, P=0.01).

Original languageEnglish (US)
Article number343501
JournalBioMed Research International
Volume2015
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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