Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease

Juana P. Sánchez-Villamil, Paula K. Bautista-Ninõ, Norma C. Serrano, Melvin Y. Rincon, Nisha J. Garg

    Research output: Contribution to journalReview article

    Abstract

    Chagas disease (CD) is one of the most important neglected tropical diseases in the American continent. Host-derived nitroxidative stress in response to Trypanosoma cruzi infection can induce tissue damage contributing to the progression of Chagas disease. Antioxidant supplementation has been suggested as adjuvant therapy to current treatment. In this article, we synthesize and discuss the current evidence regarding the use of antioxidants as adjunctive compounds to fight harmful reactive oxygen species and lower the tissue oxidative damage during progression of chronic Chagas disease. Several antioxidants evaluated in recent studies have shown potential benefits for the control of oxidative stress in the host's tissues. Melatonin, resveratrol, the combination of Vitamin C/Vitamin E (vitC/vitE) or curcumin/benznidazole, and mitochondria-targeted antioxidants seem to be beneficial in reducing plasma and cardiac levels of lipid peroxidation products. Nevertheless, further research is needed to validate beneficial effects of antioxidant therapies in Chagas disease.

    Original languageEnglish (US)
    Article number9081813
    JournalOxidative medicine and cellular longevity
    Volume2020
    DOIs
    StatePublished - Jan 1 2020

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    ASJC Scopus subject areas

    • Biochemistry
    • Aging
    • Cell Biology

    Cite this

    Sánchez-Villamil, J. P., Bautista-Ninõ, P. K., Serrano, N. C., Rincon, M. Y., & Garg, N. J. (2020). Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease. Oxidative medicine and cellular longevity, 2020, [9081813]. https://doi.org/10.1155/2020/9081813