@article{5f137a6cd25a4d4c85d6a50789d7e3d0,
title = "PPARγ agonism attenuates cocaine cue reactivity",
abstract = "Cocaine use disorder is a chronic relapsing condition characterized by compulsive drug seeking and taking even after prolonged abstinence periods. Subsequent exposure to drug-associated cues can promote intense craving and lead to relapse in abstinent humans and rodent models. The responsiveness to these cocaine-related cues, or {\textquoteleft}cue reactivity{\textquoteright}, can trigger relapse and cocaine-seeking behaviors; cue reactivity is measurable in cocaine-dependent humans as well as rodent models. Cue reactivity is thought to be predictive of cocaine craving and relapse. Here we report that PPARγ agonism during abstinence from cocaine self-administration reduced previously active lever pressing in Sprague Dawley rats during cue-reactivity tests, while administration of the PPARγ antagonist, GW9662, reversed this effect. PPARγ agonism also normalized nuclear ERK activity in the medial prefrontal cortex and hippocampus which was reversed with GW9662. Our results support the utility of PPARγ agonism as a relapse prevention strategy to maintain abstinence in the presence of cocaine-associated cues.",
keywords = "ERK MAPK, hippocampus, pioglitazone, prefrontal cortex, relapse prevention",
author = "Miller, {William R.} and Fox, {Robert G.} and Stutz, {Sonja J.} and Lane, {Scott D.} and Larry Denner and Cunningham, {Kathryn A.} and Dineley, {Kelly T.}",
note = "Funding Information: The authors declare no conflicts of interest. The Center for Addiction Research, NIDA pre-doctoral fellowship (T32-81758, WRM), NIEHS pre-doctoral fellowship (T32-ESO7254, WRM), NIDA P50-009262 (SDL), 1K05 DA020087-01 (KAC) and The McManus Charitable Trust (KTD) supported the research described herein. Funding Information: All behavioral testing was performed in the UTMB Rodent In Vivo Assessment (RIVA) Core, directed by Dr. Kelly Dineley and housed within the Center for Addiction Research, directed by Dr. Kathryn Cunningham. We wish to thank Drs. Jacqueline McGinty, Jonathan Hommel and Thomas Green for scientific and conceptual input during the development and execution of this research project. We also thank Drs. F. Gerrald Moeller, Ponanda Narayana and Joy Schmidt for helpful discussions during the writing of this manuscript. WR Miller, KT Dineley, LA Denner, and KA Cunningham designed the experiments. WR Miller, RG Fox, and S Stutz performed the research. WR Miller, KT Dineley, and KA Cunningham wrote the manuscript. SD Lane, KA Cunningham, LA Denner, and KT Dineley edited the manuscript. Publisher Copyright: {\textcopyright} 2016 Society for the Study of Addiction",
year = "2018",
month = jan,
doi = "10.1111/adb.12471",
language = "English (US)",
volume = "23",
pages = "55--68",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "1",
}