Pravastatin to prevent obstetrical complications in women with antiphospholipid syndrome

Maged M. Costantine

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Pregnant women with antiphospholipid syndrome (APS) are at a high risk of obstetrical complications. The current standard of care, including the use of low-dose aspirin and heparin, has not been shown to prevent preeclampsia or intrauterine growth restriction (IUGR). Due to the similarities in pathophysiology among preeclampsia, IUGR, and atherosclerotic cardiovascular disease, statins have been proposed for treating and/or preventing these obstetrical complications. In this issue of the JCI, Lefkou et al. report on a small, observational trial that showed a dramatic improvement in both maternal and fetal/neonatal outcomes in women with APS given pravastatin after the onset of preeclampsia and/or IUGR compared with women in the control group. These results, along with other recent clinical studies, support further evaluation of statins for prevention of preeclampsia in a large-scale randomized clinical trial.

Original languageEnglish (US)
Pages (from-to)2792-2794
Number of pages3
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • Medicine(all)


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