Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Paul W.H.I. Parren, Tom W. Geisbert, Toshiaki Maruyama, Peter B. Jahrling, Dennis R. Burton

Research output: Contribution to journalArticle

165 Scopus citations

Abstract

A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

Original languageEnglish (US)
Pages (from-to)6408-6412
Number of pages5
JournalJournal of virology
Volume76
Issue number12
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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