Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Paul W.H.I. Parren; Tom W. Geisbert; Toshiaki Maruyama; Peter B. Jahrling; Dennis R. Burton

doi:10.1128/JVI.76.12.6408-6412.2002

Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Paul W.H.I. Parren, Tom W. Geisbert, Toshiaki Maruyama, Peter B. Jahrling, Dennis R. Burton

Research output: Contribution to journal › Article › peer-review

189 Scopus citations

Abstract

A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

Original language	English (US)
Pages (from-to)	6408-6412
Number of pages	5
Journal	Journal of virology
Volume	76
Issue number	12
DOIs	https://doi.org/10.1128/JVI.76.12.6408-6412.2002
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Access to Document

10.1128/JVI.76.12.6408-6412.2002

Cite this

@article{c1981c21438b4289aa9c616e0b537549,

title = "Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody",

abstract = "A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.",

author = "Parren, {Paul W.H.I.} and Geisbert, {Tom W.} and Toshiaki Maruyama and Jahrling, {Peter B.} and Burton, {Dennis R.}",

year = "2002",

doi = "10.1128/JVI.76.12.6408-6412.2002",

language = "English (US)",

volume = "76",

pages = "6408--6412",

journal = "Journal of virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "12",

}

TY - JOUR

T1 - Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

AU - Parren, Paul W.H.I.

AU - Geisbert, Tom W.

AU - Maruyama, Toshiaki

AU - Jahrling, Peter B.

AU - Burton, Dennis R.

PY - 2002

Y1 - 2002

N2 - A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

AB - A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

UR - http://www.scopus.com/inward/record.url?scp=0036100307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036100307&partnerID=8YFLogxK

U2 - 10.1128/JVI.76.12.6408-6412.2002

DO - 10.1128/JVI.76.12.6408-6412.2002

M3 - Article

C2 - 12021376

AN - SCOPUS:0036100307

SN - 0022-538X

VL - 76

SP - 6408

EP - 6412

JO - Journal of virology

JF - Journal of virology

IS - 12

ER -

Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this