Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Paul W.H.I. Parren; Tom W. Geisbert; Toshiaki Maruyama; Peter B. Jahrling; Dennis R. Burton

doi:10.1128/JVI.76.12.6408-6412.2002

Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Paul W.H.I. Parren, Tom W. Geisbert, Toshiaki Maruyama, Peter B. Jahrling, Dennis R. Burton

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

Original language	English (US)
Pages (from-to)	6408-6412
Number of pages	5
Journal	Journal of virology
Volume	76
Issue number	12
DOIs	https://doi.org/10.1128/JVI.76.12.6408-6412.2002
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.76.12.6408-6412.2002

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AU - Jahrling, Peter B.

AU - Burton, Dennis R.

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AB - A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

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Pre- and postexposure prophylaxis of ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

Abstract

ASJC Scopus subject areas

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