Pre-eclampsia does not alter the response to endothelin-1 in human omental artery

Yuri P. Vedernikov, Michael A. Belfort, George R. Saade, Kenneth J. Moise

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Endothelin-1 (ET-1), known to be present in high concentrations in serum from preeclamptic compared with normotensive pregnant women, may contribute to the increased vascular reactivity seen in pre-eclampsia. Experiments were designed to compare the contractile activity of ET-1 in isolated omental arteries from menopausal women (n = 6), normotensive pregnant women (n = 7), and pre-eclamptic patients (n = 7). Intact rings (3-mm width) were suspended for isometric tension recording in organ chambers filled with modified Krebs/bicarbonate buffer aerated with 95% air and 5% CO2, 37°C, pH 7.35-7.4, under tension of 1 g. No significant differences were found in either the sensitivity to (concentration producing 50% of contraction) or efficacy of (maximal increase in tension, normalized to reference contraction to KC1) ET-1 in the vessels of all three groups of patients studied. These data argue against ET-1 as a primary factor in pre-eclampsia. The modulatory role of ET-1 on the effects of other contractile factors of human blood, as a possible cause of pre-eclamptic changes, remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)S233-S235
JournalJournal of cardiovascular pharmacology
Volume26
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Endothelin-1
  • Human omental artery
  • Pre-eclampsia

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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