Pre-eclampsia does not alter the response to endothelin-1 in human omental artery

Y. P. Vedernikov, M. A. Belfort, George Saade, K. J. Moise

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Endothelin-1 (ET-1), known to be present in high concentrations in serum from pre-eclamptic compared with normotensive pregnant women, may contribute to the increased vascular reactivity seen in preeclampsia. Experiments were designed to compare the contractile activity of ET-1 in isolated omental arteries from menopausal women (n = 6), normotensive pregnant women (n = 7), and pre-eclamptic patients (n = 7). Intact rings (3-mm width) were suspended for isometric tension recording in organ chambers filled with modified Krebs/bicarbonate buffer aerated with 95% air and 5% CO2, 37°C, pH 7.35- 7.4, under tension of 1 g. No significant differences were found in either the sensitivity to (concentration producing 50% of contraction) or efficacy of (maximal increase in tension, normalized to reference contraction to KCl) ET-1 in the vessels of all three groups of patients studied. These data argue against ET-1 as a primary factor in pre-eclampsia. The modulatory role of ET- 1 on the effects of other contractile factors of human blood, as a possible cause of pre-eclamptic changes, remains to be elucidated.

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Volume26
Issue numberSUPPL. 3
StatePublished - 1995
Externally publishedYes

Fingerprint

Endothelin-1
Pre-Eclampsia
Arteries
Pregnant Women
Bicarbonates
Blood Vessels
Buffers
Air
Serum

Keywords

  • Endothelin-1
  • Human omental artery
  • Pre-eclampsia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Pre-eclampsia does not alter the response to endothelin-1 in human omental artery. / Vedernikov, Y. P.; Belfort, M. A.; Saade, George; Moise, K. J.

In: Journal of Cardiovascular Pharmacology, Vol. 26, No. SUPPL. 3, 1995.

Research output: Contribution to journalArticle

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