Preconditioning with dobutamine in the isolated rat heart

G. K. Asimakis; V. R. Conti

doi:10.1016/0024-3205(95)00258-8

Preconditioning with dobutamine in the isolated rat heart

G. K. Asimakis, V. R. Conti

Surgery

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The ability of dobutamine to precondition the isolated rat heart against postischemic contractile dysfunction was assessed. Hearts were perfused with varying concentrations of dobutamine for 5 min followed by a 5 min "washout" period and 30 min of global ischemia. The hearts were reperfused for 30 min to assess postischemic function. Dobutamine improved postischemic developed pressure, +dp/dt, heart rate × developed pressure, end diastolic pressure and coronary flow in a concentration-dependent manner. The concentration of dobutamine showing the maximum protective effect was 10^-6M. Propranolol administered with dobutamine significantly attenuated the protective effect. The results indicate that transient treatment with dobutamine can precondition the rat heart against ischemia/reperfusion injury. The mechanism of protection appears to involve β-adrenergic stimulation.

Original language	English (US)
Pages (from-to)	177-187
Number of pages	11
Journal	Life Sciences
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(95)00258-8
State	Published - Jun 2 1995

Keywords

dobutamine
heart
ischemia
preconditioning

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(95)00258-8

Cite this

@article{fbd210c76f9b4d4c95df32cbe7eb05c7,

title = "Preconditioning with dobutamine in the isolated rat heart",

abstract = "The ability of dobutamine to precondition the isolated rat heart against postischemic contractile dysfunction was assessed. Hearts were perfused with varying concentrations of dobutamine for 5 min followed by a 5 min {"}washout{"} period and 30 min of global ischemia. The hearts were reperfused for 30 min to assess postischemic function. Dobutamine improved postischemic developed pressure, +dp/dt, heart rate × developed pressure, end diastolic pressure and coronary flow in a concentration-dependent manner. The concentration of dobutamine showing the maximum protective effect was 10-6M. Propranolol administered with dobutamine significantly attenuated the protective effect. The results indicate that transient treatment with dobutamine can precondition the rat heart against ischemia/reperfusion injury. The mechanism of protection appears to involve β-adrenergic stimulation.",

keywords = "dobutamine, heart, ischemia, preconditioning",

author = "Asimakis, {G. K.} and Conti, {V. R.}",

year = "1995",

month = jun,

day = "2",

doi = "10.1016/0024-3205(95)00258-8",

language = "English (US)",

volume = "57",

pages = "177--187",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Preconditioning with dobutamine in the isolated rat heart

AU - Asimakis, G. K.

AU - Conti, V. R.

PY - 1995/6/2

Y1 - 1995/6/2

N2 - The ability of dobutamine to precondition the isolated rat heart against postischemic contractile dysfunction was assessed. Hearts were perfused with varying concentrations of dobutamine for 5 min followed by a 5 min "washout" period and 30 min of global ischemia. The hearts were reperfused for 30 min to assess postischemic function. Dobutamine improved postischemic developed pressure, +dp/dt, heart rate × developed pressure, end diastolic pressure and coronary flow in a concentration-dependent manner. The concentration of dobutamine showing the maximum protective effect was 10-6M. Propranolol administered with dobutamine significantly attenuated the protective effect. The results indicate that transient treatment with dobutamine can precondition the rat heart against ischemia/reperfusion injury. The mechanism of protection appears to involve β-adrenergic stimulation.

AB - The ability of dobutamine to precondition the isolated rat heart against postischemic contractile dysfunction was assessed. Hearts were perfused with varying concentrations of dobutamine for 5 min followed by a 5 min "washout" period and 30 min of global ischemia. The hearts were reperfused for 30 min to assess postischemic function. Dobutamine improved postischemic developed pressure, +dp/dt, heart rate × developed pressure, end diastolic pressure and coronary flow in a concentration-dependent manner. The concentration of dobutamine showing the maximum protective effect was 10-6M. Propranolol administered with dobutamine significantly attenuated the protective effect. The results indicate that transient treatment with dobutamine can precondition the rat heart against ischemia/reperfusion injury. The mechanism of protection appears to involve β-adrenergic stimulation.

KW - dobutamine

KW - heart

KW - ischemia

KW - preconditioning

UR - http://www.scopus.com/inward/record.url?scp=0029031992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029031992&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(95)00258-8

DO - 10.1016/0024-3205(95)00258-8

M3 - Article

C2 - 7603297

AN - SCOPUS:0029031992

SN - 0024-3205

VL - 57

SP - 177

EP - 187

JO - Life Sciences

JF - Life Sciences

IS - 2

ER -

Preconditioning with dobutamine in the isolated rat heart

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this