Abstract
The ability of dobutamine to precondition the isolated rat heart against postischemic contractile dysfunction was assessed. Hearts were perfused with varying concentrations of dobutamine for 5 min followed by a 5 min "washout" period and 30 min of global ischemia. The hearts were reperfused for 30 min to assess postischemic function. Dobutamine improved postischemic developed pressure, +dp/dt, heart rate × developed pressure, end diastolic pressure and coronary flow in a concentration-dependent manner. The concentration of dobutamine showing the maximum protective effect was 10-6M. Propranolol administered with dobutamine significantly attenuated the protective effect. The results indicate that transient treatment with dobutamine can precondition the rat heart against ischemia/reperfusion injury. The mechanism of protection appears to involve β-adrenergic stimulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-187 |
| Number of pages | 11 |
| Journal | Life Sciences |
| Volume | 57 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2 1995 |
Keywords
- dobutamine
- heart
- ischemia
- preconditioning
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology
Fingerprint
Dive into the research topics of 'Preconditioning with dobutamine in the isolated rat heart'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS