Predicting the status of the nonsentinel axillary nodes: A multicenter study

Sandra L. Wong, Michael J. Edwards, Celia Chao, Todd M. Tuttle, R. Dirk Noyes, Claudine Woo, Patricia B. Cerrito, Kelly M. McMasters

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Background: Sentinel lymph node (SLN) biopsy is a minimally invasive procedure that provides accurate nodal staging information. The need for completion axillary dissection after finding a positive SLN for breast cancer has been questioned. Hypothesis: The presence of nonsentinel node (NSN) metastases in the axillary dissection specimen correlates with tumor size, the number of SLNs removed, and the number of positive SLNs. Design: Prospective, multi-institutional study. Participants and Methods: The University of Louisville Breast Cancer Sentinel Lymph Node Study is a nationwide study involving 148 surgeons. All patients underwent SLN biopsy, followed by level I/II axillary dissection. All SLNs were evaluated histologically at a minimum of 2-mm intervals. Immunohistochemical analysis using antibodies for cytokeratin was performed at the discretion of each participating institution. All NSNs were evaluated by routine histologic examination. Results: An SLN was identified in 1268 (90%) of 1415 patients. Increasing tumor size was significantly correlated with increasing likelihood of positive NSNs: T1a, 14%; T1b, 22%; T1c, 30%; T2, 45%; and T3, 57% (P=.002, X2 test): The presence of positive NSNs was not significantly associated with the number of SLNs removed. Patients with more than 1 positive SLN were more likely to have positive NSNs than those with only 1 positive SLN (50% vs 32%; P < .001, X2 test). Increasing tumor size and the presence of multiple positive SLNs were also associated with the presence 4 or more positive axillary nodes. Multivariate analysis confirmed that tumor size and the number of positive SLNs were independent factors predicting the presence of positive NSNs. Conclusions: The likelihood of positive NSNs correlates with increasing tumor size and the presence of multiple positive SLNs. However, even patients with small primary tumors have a substantial risk of residual axillary nodal disease after SLN biopsy. These data will be helpful in counseling patients regarding the need for completion axillary dissection after a positive SLN is identified.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalArchives of Surgery
Volume136
Issue number5
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

Wong, S. L., Edwards, M. J., Chao, C., Tuttle, T. M., Noyes, R. D., Woo, C., Cerrito, P. B., & McMasters, K. M. (2001). Predicting the status of the nonsentinel axillary nodes: A multicenter study. Archives of Surgery, 136(5), 563-568. https://doi.org/10.1001/archsurg.136.5.563