Predicting worsening asthma control following the common cold

M. J. Walter, M. Castro, S. J. Kunselman, V. M. Chinchilli, M. Reno, T. P. Ramkumar, P. C. Avila, H. A. Boushey, B. T. Ameredes, E. R. Bleecker, W. J. Calhoun, R. M. Cherniack, T. J. Craig, L. C. Denlinger, E. Israel, J. V. Fahy, N. N. Jarjour, M. Kraft, S. C. Lazarus, R. F. LemanskeR. J. Martin, S. P. Peters, J. W. Ramsdell, C. A. Sorkness, E. R. Sutherland, S. J. Szefler, S. I. Wasserman, M. E. Wechsler

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been identified. In this prospective multicentric cohort study of 413 adult subjects with asthma, the mini-Asthma Control Questionnaire (mini-ACQ) was used to quantify changes in asthma control and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) to measure cold severity. Univariate and multivariable models were used to examine demographic, physiological, serological and cold-related characteristics for their relationship to changes in asthma control following a cold. Clinically significant worsening of asthma control was observed following a cold (mean ± SD increase in mini-ACQ score of 0.69 ± 0.93). Univariate analysis demonstrated that season, centre location, cold duration and cold severity measurements were all associated with a change in asthma control. Multivariable analysis of the covariates available within the first 2 days of cold onset revealed that the day 2 and cumulative sum of day 1 and 2 WURSS-21 scores were significant predictors of the subsequent changes in asthma control. In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold. Copyright

Original languageEnglish (US)
Pages (from-to)1548-1554
Number of pages7
JournalEuropean Respiratory Journal
Issue number6
StatePublished - Dec 2008


  • Asthma
  • Asthma control
  • Common cold

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Predicting worsening asthma control following the common cold'. Together they form a unique fingerprint.

Cite this