Predicting worsening asthma control following the common cold

M. J. Walter; M. Castro; S. J. Kunselman; V. M. Chinchilli; M. Reno; T. P. Ramkumar; P. C. Avila; H. A. Boushey; B. T. Ameredes; E. R. Bleecker; W. J. Calhoun; R. M. Cherniack; T. J. Craig; L. C. Denlinger; E. Israel; J. V. Fahy; N. N. Jarjour; M. Kraft; S. C. Lazarus; R. F. Lemanske; R. J. Martin; S. P. Peters; J. W. Ramsdell; C. A. Sorkness; E. R. Sutherland; S. J. Szefler; S. I. Wasserman; M. E. Wechsler

doi:10.1183/09031936.00026808

Predicting worsening asthma control following the common cold

M. J. Walter
, M. Castro
, S. J. Kunselman
, V. M. Chinchilli
, M. Reno
, T. P. Ramkumar
, P. C. Avila
, H. A. Boushey
, B. T. Ameredes
, E. R. Bleecker
, W. J. Calhoun
, R. M. Cherniack
, T. J. Craig
, L. C. Denlinger
, E. Israel
, J. V. Fahy
, N. N. Jarjour
, M. Kraft
, S. C. Lazarus
, R. F. Lemanske

R. J. Martin, S. P. Peters, J. W. Ramsdell, C. A. Sorkness, E. R. Sutherland, S. J. Szefler, S. I. Wasserman, M. E. Wechsler

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been identified. In this prospective multicentric cohort study of 413 adult subjects with asthma, the mini-Asthma Control Questionnaire (mini-ACQ) was used to quantify changes in asthma control and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) to measure cold severity. Univariate and multivariable models were used to examine demographic, physiological, serological and cold-related characteristics for their relationship to changes in asthma control following a cold. Clinically significant worsening of asthma control was observed following a cold (mean ± SD increase in mini-ACQ score of 0.69 ± 0.93). Univariate analysis demonstrated that season, centre location, cold duration and cold severity measurements were all associated with a change in asthma control. Multivariable analysis of the covariates available within the first 2 days of cold onset revealed that the day 2 and cumulative sum of day 1 and 2 WURSS-21 scores were significant predictors of the subsequent changes in asthma control. In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold. Copyright

Original language	English (US)
Pages (from-to)	1548-1554
Number of pages	7
Journal	European Respiratory Journal
Volume	32
Issue number	6
DOIs	https://doi.org/10.1183/09031936.00026808
State	Published - Dec 2008

Keywords

Asthma
Asthma control
Common cold

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.00026808

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Walter, M. J., Castro, M., Kunselman, S. J., Chinchilli, V. M., Reno, M., Ramkumar, T. P., Avila, P. C., Boushey, H. A., Ameredes, B. T., Bleecker, E. R., Calhoun, W. J., Cherniack, R. M., Craig, T. J., Denlinger, L. C., Israel, E., Fahy, J. V., Jarjour, N. N., Kraft, M., Lazarus, S. C., ... Wechsler, M. E. (2008). Predicting worsening asthma control following the common cold. European Respiratory Journal, 32(6), 1548-1554. https://doi.org/10.1183/09031936.00026808

Walter, MJ, Castro, M, Kunselman, SJ, Chinchilli, VM, Reno, M, Ramkumar, TP, Avila, PC, Boushey, HA, Ameredes, BT, Bleecker, ER, Calhoun, WJ, Cherniack, RM, Craig, TJ, Denlinger, LC, Israel, E, Fahy, JV, Jarjour, NN, Kraft, M, Lazarus, SC, Lemanske, RF, Martin, RJ, Peters, SP, Ramsdell, JW, Sorkness, CA, Sutherland, ER, Szefler, SJ, Wasserman, SI & Wechsler, ME 2008, 'Predicting worsening asthma control following the common cold', European Respiratory Journal, vol. 32, no. 6, pp. 1548-1554. https://doi.org/10.1183/09031936.00026808

@article{5686301646bb4552b92c51266b665e16,

title = "Predicting worsening asthma control following the common cold",

abstract = "The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been identified. In this prospective multicentric cohort study of 413 adult subjects with asthma, the mini-Asthma Control Questionnaire (mini-ACQ) was used to quantify changes in asthma control and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) to measure cold severity. Univariate and multivariable models were used to examine demographic, physiological, serological and cold-related characteristics for their relationship to changes in asthma control following a cold. Clinically significant worsening of asthma control was observed following a cold (mean ± SD increase in mini-ACQ score of 0.69 ± 0.93). Univariate analysis demonstrated that season, centre location, cold duration and cold severity measurements were all associated with a change in asthma control. Multivariable analysis of the covariates available within the first 2 days of cold onset revealed that the day 2 and cumulative sum of day 1 and 2 WURSS-21 scores were significant predictors of the subsequent changes in asthma control. In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold. Copyright",

keywords = "Asthma, Asthma control, Common cold",

author = "Walter, \{M. J.\} and M. Castro and Kunselman, \{S. J.\} and Chinchilli, \{V. M.\} and M. Reno and Ramkumar, \{T. P.\} and Avila, \{P. C.\} and Boushey, \{H. A.\} and Ameredes, \{B. T.\} and Bleecker, \{E. R.\} and Calhoun, \{W. J.\} and Cherniack, \{R. M.\} and Craig, \{T. J.\} and Denlinger, \{L. C.\} and E. Israel and Fahy, \{J. V.\} and Jarjour, \{N. N.\} and M. Kraft and Lazarus, \{S. C.\} and Lemanske, \{R. F.\} and Martin, \{R. J.\} and Peters, \{S. P.\} and Ramsdell, \{J. W.\} and Sorkness, \{C. A.\} and Sutherland, \{E. R.\} and Szefler, \{S. J.\} and Wasserman, \{S. I.\} and Wechsler, \{M. E.\}",

year = "2008",

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doi = "10.1183/09031936.00026808",

language = "English (US)",

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AU - Walter, M. J.

AU - Castro, M.

AU - Kunselman, S. J.

AU - Chinchilli, V. M.

AU - Reno, M.

AU - Ramkumar, T. P.

AU - Avila, P. C.

AU - Boushey, H. A.

AU - Ameredes, B. T.

AU - Bleecker, E. R.

AU - Calhoun, W. J.

AU - Cherniack, R. M.

AU - Craig, T. J.

AU - Denlinger, L. C.

AU - Israel, E.

AU - Fahy, J. V.

AU - Jarjour, N. N.

AU - Kraft, M.

AU - Lazarus, S. C.

AU - Lemanske, R. F.

AU - Martin, R. J.

AU - Peters, S. P.

AU - Ramsdell, J. W.

AU - Sorkness, C. A.

AU - Sutherland, E. R.

AU - Szefler, S. J.

AU - Wasserman, S. I.

AU - Wechsler, M. E.

PY - 2008/12

Y1 - 2008/12

N2 - The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been identified. In this prospective multicentric cohort study of 413 adult subjects with asthma, the mini-Asthma Control Questionnaire (mini-ACQ) was used to quantify changes in asthma control and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) to measure cold severity. Univariate and multivariable models were used to examine demographic, physiological, serological and cold-related characteristics for their relationship to changes in asthma control following a cold. Clinically significant worsening of asthma control was observed following a cold (mean ± SD increase in mini-ACQ score of 0.69 ± 0.93). Univariate analysis demonstrated that season, centre location, cold duration and cold severity measurements were all associated with a change in asthma control. Multivariable analysis of the covariates available within the first 2 days of cold onset revealed that the day 2 and cumulative sum of day 1 and 2 WURSS-21 scores were significant predictors of the subsequent changes in asthma control. In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold. Copyright

AB - The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been identified. In this prospective multicentric cohort study of 413 adult subjects with asthma, the mini-Asthma Control Questionnaire (mini-ACQ) was used to quantify changes in asthma control and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) to measure cold severity. Univariate and multivariable models were used to examine demographic, physiological, serological and cold-related characteristics for their relationship to changes in asthma control following a cold. Clinically significant worsening of asthma control was observed following a cold (mean ± SD increase in mini-ACQ score of 0.69 ± 0.93). Univariate analysis demonstrated that season, centre location, cold duration and cold severity measurements were all associated with a change in asthma control. Multivariable analysis of the covariates available within the first 2 days of cold onset revealed that the day 2 and cumulative sum of day 1 and 2 WURSS-21 scores were significant predictors of the subsequent changes in asthma control. In asthmatic subjects, cold severity within the first 2 days can be used to predict subsequent changes in asthma control. This information may help clinicians prevent deterioration in asthma control following a cold. Copyright

KW - Asthma

KW - Asthma control

KW - Common cold

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SN - 0903-1936

VL - 32

SP - 1548

EP - 1554

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 6

ER -

Predicting worsening asthma control following the common cold

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