Predictive factors of incomplete aneurysm occlusion after endovascular treatment with the Pipeline embolization device

Georgios A. Maragkos, Luis C. Ascanio, Mohamed M. Salem, Sricharan Gopakumar, Santiago Gomez-Paz, Alejandro Enriquez-Marulanda, Abhi Jain, Clemens M. Schirmer, Paul M. Foreman, Christoph J. Griessenauer, Peter Kan, Christopher S. Ogilvy, Ajith J. Thomas

Research output: Contribution to journalArticle

Abstract

OBJECTIVE The Pipeline embolization device (PED) is a routine choice for the endovascular treatment of select intracranial aneurysms. Its success is based on the high rates of aneurysm occlusion, followed by near-zero recanalization probability once occlusion has occurred. Therefore, identification of patient factors predictive of incomplete occlusion on the last angiographic follow-up is critical to its success. METHODS A multicenter retrospective cohort analysis was conducted on consecutive patients treated with a PED for unruptured aneurysms in 3 academic institutions in the US. Patients with angiographic follow-up were selected to identify the factors associated with incomplete occlusion. RESULTS Among all 3 participating institutions a total of 523 PED placement procedures were identified. There were 284 procedures for 316 aneurysms, which had radiographic follow-up and were included in this analysis (median age 58 years; female-to-male ratio 4.2:1). Complete occlusion (100% occlusion) was noted in 76.6% of aneurysms, whereas incomplete occlusion (≤ 99% occlusion) at last follow-up was identified in 23.4%. After accounting for factor collinearity and confounding, multivariable analysis identified older age (> 70 years; OR 4.46, 95% CI 2.30–8.65, p < 0.001); higher maximal diameter (≥ 15 mm; OR 3.29, 95% CI 1.43–7.55, p = 0.005); and fusiform morphology (OR 2.89, 95% CI 1.06–7.85, p = 0.038) to be independently associated with higher rates of incomplete occlusion at last follow-up. Thromboembolic complications were noted in 1.4% and hemorrhagic complications were found in 0.7% of procedures. CONCLUSIONS Incomplete aneurysm occlusion following placement of a PED was independently associated with age > 70 years, aneurysm diameter ≥ 15 mm, and fusiform morphology. Such predictive factors can be used to guide individualized treatment selection and counseling in patients undergoing cerebrovascular neurosurgery.

Original languageEnglish (US)
Pages (from-to)1598-1605
Number of pages8
JournalJournal of neurosurgery
Volume132
Issue number5
DOIs
StatePublished - May 2020
Externally publishedYes

Keywords

  • Aneurysm
  • Interventional neurosurgery
  • Occlusion
  • Pipeline embolization device
  • Prognostic factors
  • Vascular disorders

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    Maragkos, G. A., Ascanio, L. C., Salem, M. M., Gopakumar, S., Gomez-Paz, S., Enriquez-Marulanda, A., Jain, A., Schirmer, C. M., Foreman, P. M., Griessenauer, C. J., Kan, P., Ogilvy, C. S., & Thomas, A. J. (2020). Predictive factors of incomplete aneurysm occlusion after endovascular treatment with the Pipeline embolization device. Journal of neurosurgery, 132(5), 1598-1605. https://doi.org/10.3171/2019.1.JNS183226