Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury

Matthias Lange, Robert A. Cox, Perenlei Enkhbaatar, Elbert B. Whorton, Yoshimitsu Nakano, Atsumori Hamahata, Collette Jonkam, Aimalohi Esechie, Sanna Von Borzyskowski, Lillian D. Traber, Daniel L. Traber

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Inhalation injury frequently occurs in burn patients and contributes to the morbidity and mortality of these injuries. Arterial carboxyhemoglobin has been proposed as an indicator of the severity of inhalation injury; however, the interrelation between arterial carboxyhemoglobin and histological alterations has not yet been investigated. Chronically instrumented sheep were subjected to a third degree burn of 40% of the total body surface area and inhalation of 48 breaths of cotton smoke. Carboxyhemoglobin was measured immediately after injury and correlated to clinical parameters of pulmonary function as well as histopathology scores from lung tissue harvested 24 hours after the injury. The injury was associated with a significant decline in pulmonary oxygenation and increases in pulmonary shunting, lung lymph flow, wet/dry weight ratio, congestion score, edema score, inflammation score, and airway obstruction scores. Carboxyhemoglobin was negatively correlated to pulmonary oxygenation and positively correlated to pulmonary shunting, lung lymph flow, and lung wet/dry weight ratio. No significant correlations could be detected between carboxyhemoglobin and histopathology scores and airway obstruction scores. Arterial carboxyhemoglobin in sheep with combined burn and inhalation injury are correlated with the degree of pulmonary failure and edema formation, but not with certain histological alterations including airway obstruction scores.

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalExperimental Lung Research
Volume37
Issue number4
DOIs
StatePublished - May 2011

Fingerprint

Inhalation Burns
Carboxyhemoglobin
Lung Injury
Smoke
Sheep
Lung
Wounds and Injuries
Airway Obstruction
Oxygenation
Inhalation
Lymph
Pulmonary Edema
Weights and Measures
Cotton
Body Surface Area
Tissue
Edema
Inflammation
Morbidity

Keywords

  • carbon monoxide
  • inhalation injury
  • pulmonary failure
  • sheep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury. / Lange, Matthias; Cox, Robert A.; Enkhbaatar, Perenlei; Whorton, Elbert B.; Nakano, Yoshimitsu; Hamahata, Atsumori; Jonkam, Collette; Esechie, Aimalohi; Von Borzyskowski, Sanna; Traber, Lillian D.; Traber, Daniel L.

In: Experimental Lung Research, Vol. 37, No. 4, 05.2011, p. 239-245.

Research output: Contribution to journalArticle

Lange, M, Cox, RA, Enkhbaatar, P, Whorton, EB, Nakano, Y, Hamahata, A, Jonkam, C, Esechie, A, Von Borzyskowski, S, Traber, LD & Traber, DL 2011, 'Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury', Experimental Lung Research, vol. 37, no. 4, pp. 239-245. https://doi.org/10.3109/01902148.2010.538133
Lange, Matthias ; Cox, Robert A. ; Enkhbaatar, Perenlei ; Whorton, Elbert B. ; Nakano, Yoshimitsu ; Hamahata, Atsumori ; Jonkam, Collette ; Esechie, Aimalohi ; Von Borzyskowski, Sanna ; Traber, Lillian D. ; Traber, Daniel L. / Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury. In: Experimental Lung Research. 2011 ; Vol. 37, No. 4. pp. 239-245.
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