Predictive value of IL-8 for sepsis and severe infections after burn injury

A clinical study

Robert Kraft, David Herndon, Celeste Finnerty, Robert A. Cox, Juquan Song, Marc G. Jeschke

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The inflammatory response induced by burn injury contributes to increased incidence of infections, sepsis, organ failure, and mortality. Thus, monitoring postburn inflammation is of paramount importance but, so far, there are no reliable biomarkers available to monitor and/or predict infectious complications after burn. As interleukin 8 (IL-8) is a major mediator for inflammatory responses, the aim of our study was to determine whether IL-8 expression can be used to predict postburn sepsis, infections, and mortality. Plasma cytokines, acute-phase proteins, constitutive proteins, and hormones were analyzed during the first 60 days after injury from 468 pediatric burn patients. Demographics and clinical outcome variables (length of stay, infection, sepsis, multiorgan failure [MOF], and mortality) were recorded. A cutoff level for IL-8 was determined using receiver operating characteristic analysis. Statistical significance is set at P < 0.05. Receiver operating characteristic analysis identified a cutoff level of 234 pg/mL for IL-8 for survival. Patients were grouped according to their average IL-8 levels relative to this cutoff and stratified into high (H) (n = 133) and low (L) (n = 335) groups. In the L group, regression analysis revealed a significant predictive value of IL-8 to percent of total body surface area burned and incidence of MOF (P < 0.001). In the H group, IL-8 levels were able to predict sepsis (P < 0.002). In the H group, elevated IL-8 was associated with increased inflammatory and acute-phase responses compared with the L group (P < 0.05). High levels of IL-8 correlated with increased MOF, sepsis, and mortality. These data suggest that serum levels of IL-8 may be a valid biomarker for monitoring sepsis, infections, and mortality in burn patients.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalShock
Volume43
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Interleukin-8
Sepsis
Wounds and Injuries
Infection
Mortality
ROC Curve
Biomarkers
Clinical Studies
Acute-Phase Reaction
Acute-Phase Proteins
Body Surface Area
Incidence
Length of Stay
Regression Analysis
Demography
Hormones
Pediatrics
Cytokines
Inflammation
Survival

Keywords

  • Biomarker
  • Burn
  • IL-8
  • Infection
  • MOF
  • Mortality
  • Organ failure
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Predictive value of IL-8 for sepsis and severe infections after burn injury : A clinical study. / Kraft, Robert; Herndon, David; Finnerty, Celeste; Cox, Robert A.; Song, Juquan; Jeschke, Marc G.

In: Shock, Vol. 43, No. 3, 01.03.2015, p. 222-227.

Research output: Contribution to journalArticle

Kraft, Robert ; Herndon, David ; Finnerty, Celeste ; Cox, Robert A. ; Song, Juquan ; Jeschke, Marc G. / Predictive value of IL-8 for sepsis and severe infections after burn injury : A clinical study. In: Shock. 2015 ; Vol. 43, No. 3. pp. 222-227.
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