Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis

Erdem Tüzün; Shamsher S. Saini; Sidharth Ghosh; Julie Rowin; Matthew N. Meriggioli; Premkumar Christadoss

doi:10.1016/j.nmd.2005.11.005

Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis

Erdem Tüzün, Shamsher S. Saini, Sidharth Ghosh, Julie Rowin, Matthew N. Meriggioli, Premkumar Christadoss

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.

Original language	English (US)
Pages (from-to)	137-143
Number of pages	7
Journal	Neuromuscular Disorders
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.nmd.2005.11.005
State	Published - Feb 2006
Externally published	Yes

Keywords

Anti-C1q antibody
Autoimmunity
Circulating immune complexes
Experimental autoimmune myasthenia gravis
Myasthenia gravis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Clinical Neurology
Genetics(clinical)

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10.1016/j.nmd.2005.11.005

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title = "Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis",

abstract = "Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.",

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AU - Ghosh, Sidharth

AU - Rowin, Julie

AU - Meriggioli, Matthew N.

AU - Christadoss, Premkumar

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N2 - Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.

AB - Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.

KW - Anti-C1q antibody

KW - Autoimmunity

KW - Circulating immune complexes

KW - Experimental autoimmune myasthenia gravis

KW - Myasthenia gravis

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Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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