Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis

Erdem Tüzün, Shamsher S. Saini, Sidharth Ghosh, Julie Rowin, Matthew N. Meriggioli, Premkumar Christadoss

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalNeuromuscular Disorders
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2006

Keywords

  • Anti-C1q antibody
  • Autoimmunity
  • Circulating immune complexes
  • Experimental autoimmune myasthenia gravis
  • Myasthenia gravis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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    Tüzün, E., Saini, S. S., Ghosh, S., Rowin, J., Meriggioli, M. N., & Christadoss, P. (2006). Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis. Neuromuscular Disorders, 16(2), 137-143. https://doi.org/10.1016/j.nmd.2005.11.005