Predictors and impact of aspiration pneumonia in patients undergoing esophagogastroduodenoscopy: national inpatient sample 2016-2020

Jay Patel, Aalam Sohal, Hunza Chaudhry, Shivam Kalra, Isha Kohli, Ishandeep Singh, Dino Dukovic, Juliana Yang

Research output: Contribution to journalArticlepeer-review


Objectives Aspiration pneumonia is a rare but feared complication among patients undergoing esophagogastroduodenoscopy (EGD). Our study aims to assess the incidence as well as risk factors for aspiration pneumonia in patients undergoing EGD. Methods National Inpatient Sample 2016-2020 was used to identify adult patients undergoing EGD. Patients were stratified into two groups based on the presence of aspiration pneumonia. Multivariate logistic regression analysis was performed to identify the risk factors associated with aspiration pneumonia. We adjusted for patient demographics, Elixhauser comorbidities and hospital characteristics. Results Of the 1.8 million patients undergoing EGD, 1.9% of the patients developed aspiration pneumonia. Patients with aspiration pneumonia were mostly males (59.54%), aged >65 years old (66.19%), White (72.2%), had Medicare insurance (70.5%) and were in the lowest income quartile (28.7%). On multivariate analysis, the age >65 group, White race, congestive heart failure (CHF), neurological disorders and chronic obstructive pulmonary disease were associated with higher odds of aspiration pneumonia. This complication was associated with higher in-hospital mortality (9% vs. 0.8%; P < 0.001) and longer length of stay (10.54 days vs. 4.85 days; P < 0.001). Conclusion Our study found that rates of post-EGD aspiration pneumonia are increasing. We found a significant association between various comorbidities and aspiration pneumonia. Our data suggests that we need to optimize these patients before EGD, as the development of aspiration is associated with worsened outcomes. Further prospective studies are needed to clarify these associations.

Original languageEnglish (US)
Pages (from-to)298-305
Number of pages8
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number3
StatePublished - Mar 1 2024


  • aspiration pneumonia
  • endoscopy
  • impact
  • National Inpatient Sample
  • predictors
  • trends

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Predictors and impact of aspiration pneumonia in patients undergoing esophagogastroduodenoscopy: national inpatient sample 2016-2020'. Together they form a unique fingerprint.

Cite this