Predictors for the Development of Elevated Anti-Heparin/Platelet Factor 4 Antibody Titers in Patients Undergoing Cardiac Catheterization

Robert W. Yeh, Brendan M. Everett, Shi Yin Foo, David J. Dorer, Michael Laposata, Elizabeth M. Van Cott, Ik Kyung Jang

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A substantial proportion of patients who undergo cardiac catheterization develop antibodies directed against the heparin/platelet factor 4 (PF4) complex after the procedure, which have been implicated in the pathogenesis of heparin-induced thrombocytopenia. This study attempted to identify factors that predicted the development of these antibodies in a prospective cohort study. Antiheparin/PF4 antibody titers were measured at baseline and again 5 ± 2 days after cardiac catheterization by enzyme-linked immunosorbent assay. A total of 311 patients who underwent cardiac catheterization were included in the analysis. Of these, 25 (8.0%) developed positive antibody levels after catheterization. Patients who had positive antibody test results after catheterization had significantly greater baseline antiheparin/PF4 antibody titers compared with those whose titers remained low (optical density 0.227 vs 0.158, p <0.001). In a logistic regression model, greater baseline antibody titers, a history of heparin exposure, and a lower platelet count at enrollment were the strongest predictors of conversion to positive antiheparin/PF4 antibody titers after cardiac catheterization. It is possible to identify patients at high risk for developing elevated titers of antiheparin/PF4 antibodies on the basis of their baseline clinical characteristics.

Original languageEnglish (US)
Pages (from-to)419-421
Number of pages3
JournalAmerican Journal of Cardiology
Volume98
Issue number3
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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