Preeclampsia: Pathophysiology, management, and maternal and fetal sequelae

Mollie McDonnold, Gayle Olson

Research output: Contribution to journalArticle

Abstract

Preeclampsia is a unique, complicated problem of pregnancy that is prevalent worldwide. The maternal effects of severe disease may involve multiple organ systems. Consequences of disease for the infant include possible prematurity, fetal growth restriction, placental abruption, or intrauterine fetal demise. In addition, long-termeffects of disease have been studied in both mothers and children. Although the exact cause of preeclampsia is not fully understood, increasing evidence points to abnormal placentation and an imbalance of antiangiogenic factors. Specifically, soluble Fms-like tyrosine kinase-1 has been investigated as the link between poor placental invasion and maternal disease. Clinically, maternal disease is defined as the presence of elevated blood pressure after 20 weeks' gestation and proteinuria. The presence of severe symptoms or abnormal laboratory test results separate mild and severe disease. Studies have shown that delivery should occur at 37 weeks' gestation with mild disease and 34 weeks' gestation with severe disease. In early-onset severe disease, expectant management with close monitoring is possible if maternal and fetal status remain stable. Pathophysiology, diagnosis criteria, management, and possible maternal and fetal complications are reviewed.

Original languageEnglish (US)
JournalNeoReviews
Volume14
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Pre-Eclampsia
Mothers
Pregnancy
Abruptio Placentae
Vascular Endothelial Growth Factor Receptor-1
Placentation
Fetal Death
Disease Management
Fetal Development
Proteinuria
Blood Pressure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Preeclampsia : Pathophysiology, management, and maternal and fetal sequelae. / McDonnold, Mollie; Olson, Gayle.

In: NeoReviews, Vol. 14, No. 1, 01.2013.

Research output: Contribution to journalArticle

@article{6ba7e854e10d4a4a98c7f4243d5cb17a,
title = "Preeclampsia: Pathophysiology, management, and maternal and fetal sequelae",
abstract = "Preeclampsia is a unique, complicated problem of pregnancy that is prevalent worldwide. The maternal effects of severe disease may involve multiple organ systems. Consequences of disease for the infant include possible prematurity, fetal growth restriction, placental abruption, or intrauterine fetal demise. In addition, long-termeffects of disease have been studied in both mothers and children. Although the exact cause of preeclampsia is not fully understood, increasing evidence points to abnormal placentation and an imbalance of antiangiogenic factors. Specifically, soluble Fms-like tyrosine kinase-1 has been investigated as the link between poor placental invasion and maternal disease. Clinically, maternal disease is defined as the presence of elevated blood pressure after 20 weeks' gestation and proteinuria. The presence of severe symptoms or abnormal laboratory test results separate mild and severe disease. Studies have shown that delivery should occur at 37 weeks' gestation with mild disease and 34 weeks' gestation with severe disease. In early-onset severe disease, expectant management with close monitoring is possible if maternal and fetal status remain stable. Pathophysiology, diagnosis criteria, management, and possible maternal and fetal complications are reviewed.",
author = "Mollie McDonnold and Gayle Olson",
year = "2013",
month = "1",
doi = "10.1542/neo.14-1-e4",
language = "English (US)",
volume = "14",
journal = "Pediatrics in Review",
issn = "0191-9601",
publisher = "American Academy of Pediatrics",
number = "1",

}

TY - JOUR

T1 - Preeclampsia

T2 - Pathophysiology, management, and maternal and fetal sequelae

AU - McDonnold, Mollie

AU - Olson, Gayle

PY - 2013/1

Y1 - 2013/1

N2 - Preeclampsia is a unique, complicated problem of pregnancy that is prevalent worldwide. The maternal effects of severe disease may involve multiple organ systems. Consequences of disease for the infant include possible prematurity, fetal growth restriction, placental abruption, or intrauterine fetal demise. In addition, long-termeffects of disease have been studied in both mothers and children. Although the exact cause of preeclampsia is not fully understood, increasing evidence points to abnormal placentation and an imbalance of antiangiogenic factors. Specifically, soluble Fms-like tyrosine kinase-1 has been investigated as the link between poor placental invasion and maternal disease. Clinically, maternal disease is defined as the presence of elevated blood pressure after 20 weeks' gestation and proteinuria. The presence of severe symptoms or abnormal laboratory test results separate mild and severe disease. Studies have shown that delivery should occur at 37 weeks' gestation with mild disease and 34 weeks' gestation with severe disease. In early-onset severe disease, expectant management with close monitoring is possible if maternal and fetal status remain stable. Pathophysiology, diagnosis criteria, management, and possible maternal and fetal complications are reviewed.

AB - Preeclampsia is a unique, complicated problem of pregnancy that is prevalent worldwide. The maternal effects of severe disease may involve multiple organ systems. Consequences of disease for the infant include possible prematurity, fetal growth restriction, placental abruption, or intrauterine fetal demise. In addition, long-termeffects of disease have been studied in both mothers and children. Although the exact cause of preeclampsia is not fully understood, increasing evidence points to abnormal placentation and an imbalance of antiangiogenic factors. Specifically, soluble Fms-like tyrosine kinase-1 has been investigated as the link between poor placental invasion and maternal disease. Clinically, maternal disease is defined as the presence of elevated blood pressure after 20 weeks' gestation and proteinuria. The presence of severe symptoms or abnormal laboratory test results separate mild and severe disease. Studies have shown that delivery should occur at 37 weeks' gestation with mild disease and 34 weeks' gestation with severe disease. In early-onset severe disease, expectant management with close monitoring is possible if maternal and fetal status remain stable. Pathophysiology, diagnosis criteria, management, and possible maternal and fetal complications are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=84873874006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873874006&partnerID=8YFLogxK

U2 - 10.1542/neo.14-1-e4

DO - 10.1542/neo.14-1-e4

M3 - Article

AN - SCOPUS:84873874006

VL - 14

JO - Pediatrics in Review

JF - Pediatrics in Review

SN - 0191-9601

IS - 1

ER -