Abstract
Objective: Preeclampsia is a multisystemic disorder of unknown etiology. The objective of this study was to determine the role of some interleukins (IL-2, IL-10) in the etiology of preeclampsia from an immunmodulatuar view. Material and Methods: The study group consisted of 44 pregnant women with preeclampsia (25 mild, 12 severe and 7 HELLP syndrome), 44 healthy pregnant women comprised the control group. The serum concentration of IL-2 and IL-10 was measured with chemiluminescent immunassay procedure. Results: The serum IL-2 concentration was significantly higher in the women with preeclampsia compare with normotensive pregnancies (p<0.001). Concentrations of serum IL- 10 were similar in both groups. The balance of Th1/Th2 shifted to Th1 type immunity in preeclamptic pregnancies and in normotensive pregnancies the balance of Th1/Th2 shifted to Th2 type immunity. There were no significant differences observed in the Th1/Th2 balance among mild preeclampsia, severe preeclampsia and HELLP groups. Conclusion: These results suggest that in patients with preeclampsia there is Th1/Th2 imbalance with predominant-preinflamatory Th1 immunity. Development in understanding the pathophysiology of preeclampsia could improve maternal and fetal well-being.
Translated title of the contribution | Serum IL-2, IL-10 concentration and Th1/Th2 balance in preeclampsia |
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Original language | Turkish |
Pages (from-to) | 1-7 |
Number of pages | 7 |
Journal | Turkiye Klinikleri Jinekoloji Obstetrik |
Volume | 22 |
Issue number | 1 |
State | Published - 2012 |
Externally published | Yes |
Keywords
- Interleukin-10
- Interleukin-2
- Preeclampsia
- Th1 cells
- Th2 cells
ASJC Scopus subject areas
- Obstetrics and Gynecology