Preeklampside maternal serum IL-2, IL-10 konsantrasyonlari ve Th1/Th2 dengesi

Translated title of the contribution: Serum IL-2, IL-10 concentration and Th1/Th2 balance in preeclampsia

Alper Başbuǧ, Derya Başbuǧ, Bekir Serdar Ünlü, Sunullah Soysal, Muammer M. Doǧan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: Preeclampsia is a multisystemic disorder of unknown etiology. The objective of this study was to determine the role of some interleukins (IL-2, IL-10) in the etiology of preeclampsia from an immunmodulatuar view. Material and Methods: The study group consisted of 44 pregnant women with preeclampsia (25 mild, 12 severe and 7 HELLP syndrome), 44 healthy pregnant women comprised the control group. The serum concentration of IL-2 and IL-10 was measured with chemiluminescent immunassay procedure. Results: The serum IL-2 concentration was significantly higher in the women with preeclampsia compare with normotensive pregnancies (p<0.001). Concentrations of serum IL- 10 were similar in both groups. The balance of Th1/Th2 shifted to Th1 type immunity in preeclamptic pregnancies and in normotensive pregnancies the balance of Th1/Th2 shifted to Th2 type immunity. There were no significant differences observed in the Th1/Th2 balance among mild preeclampsia, severe preeclampsia and HELLP groups. Conclusion: These results suggest that in patients with preeclampsia there is Th1/Th2 imbalance with predominant-preinflamatory Th1 immunity. Development in understanding the pathophysiology of preeclampsia could improve maternal and fetal well-being.

Translated title of the contributionSerum IL-2, IL-10 concentration and Th1/Th2 balance in preeclampsia
Original languageTurkish
Pages (from-to)1-7
Number of pages7
JournalTurkiye Klinikleri Jinekoloji Obstetrik
Volume22
Issue number1
StatePublished - 2012
Externally publishedYes

Keywords

  • Interleukin-10
  • Interleukin-2
  • Preeclampsia
  • Th1 cells
  • Th2 cells

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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