Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells

Chien-Te Tseng, O. J. Fletcher, L. W. Schierman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F1offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F1) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.

Original languageEnglish (US)
Pages (from-to)557-567
Number of pages11
JournalAvian Pathology
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Marek Disease
Mardivirus
Marek disease
Immunization
immunization
pathogenesis
Viruses
viruses
immunity
antigens
Immunity
bursa of Fabricius
viremia
major histocompatibility complex
cells
Bursa of Fabricius
virus replication
lymphoma
lesions (animal)
inbred lines

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology and Microbiology(all)
  • Food Animals

Cite this

Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells. / Tseng, Chien-Te; Fletcher, O. J.; Schierman, L. W.

In: Avian Pathology, Vol. 15, No. 3, 01.01.1986, p. 557-567.

Research output: Contribution to journalArticle

@article{30deb12ab1d645e2b7d076ad5be01d3d,
title = "Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells",
abstract = "The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F1offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F1) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.",
author = "Chien-Te Tseng and Fletcher, {O. J.} and Schierman, {L. W.}",
year = "1986",
month = "1",
day = "1",
doi = "10.1080/03079458608436315",
language = "English (US)",
volume = "15",
pages = "557--567",
journal = "Avian Pathology",
issn = "0307-9457",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells

AU - Tseng, Chien-Te

AU - Fletcher, O. J.

AU - Schierman, L. W.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F1offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F1) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.

AB - The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F1offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F1) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.

UR - http://www.scopus.com/inward/record.url?scp=0006751222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0006751222&partnerID=8YFLogxK

U2 - 10.1080/03079458608436315

DO - 10.1080/03079458608436315

M3 - Article

VL - 15

SP - 557

EP - 567

JO - Avian Pathology

JF - Avian Pathology

SN - 0307-9457

IS - 3

ER -