Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells

C. K. Tseng; O. J. Fletcher; L. W. Schierman

doi:10.1080/03079458608436315

Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells

C. K. Tseng, O. J. Fletcher, L. W. Schierman

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F₁offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F₁) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.

Original language	English (US)
Pages (from-to)	557-567
Number of pages	11
Journal	Avian Pathology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1080/03079458608436315
State	Published - Jan 1 1986
Externally published	Yes

ASJC Scopus subject areas

Food Animals
Animal Science and Zoology
General Immunology and Microbiology

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abstract = "The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F1offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F1) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.",

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AB - The effect of immunisation with virus non-producer Marek's disease (MD) lymphoma-derived lymphoblastoid cells on virus replication and lymphoid organ pathogenesis following MD virus challenge was studied with chickens from two related inbred lines and their F1offspring. Protection against peripheral blood lymphocyte-associated viraemia as well as MD virus-caused weight changes of the spleen and bursa of Fabricius and degenerative bursal lesions was significantly greater among syngeneic and semi-syngeneic (F1) recipients than among allogeneic recipients of the lymphoblastoid cells. The results suggest that the protective immunity observed may be major histocompatibility complex (MHC) antigen-restricted and that non-infectious MD virus-transformed cells possess antigens that can induce anti-viral immunity.

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Preferential protection against marek's disease pathogenesis by immunisation with syngeneic virus-nonproducer lymphoblastoid cells

Abstract

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