Prefilament tau species as potential targets for immunotherapy for Alzheimer disease and related disorders

Rakez Kayed, George R. Jackson

    Research output: Contribution to journalReview articlepeer-review

    44 Scopus citations

    Abstract

    Alzheimer disease (AD) is the most common neurodegenerative disorder. Currently available therapies may slow cognitive decline but do not alter underlying disease processes. Considerable effort over the last decade has been directed toward the development of vaccines for AD; these have been primarily directed against the Aβ peptide, a component of senile plaques. More recently, alternative approaches have begun to target the microtubule binding protein tau, a component of neurofibrillary tangles. Immunotherapies based upon oligomeric species of tau represent a promising new approach for AD.

    Original languageEnglish (US)
    Pages (from-to)359-363
    Number of pages5
    JournalCurrent Opinion in Immunology
    Volume21
    Issue number3
    DOIs
    StatePublished - Jun 2009

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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