Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome

Madeline Murguia Rice, Mark B. Landon, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Joseph R. Biggio, John M. Thorp, Edward K. Chien, George Saade, Alan M. Peaceman, Sean C. Blackwell, J. Peter Vandorsten

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47% of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29%) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95% confidence interval [CI] 1.95-4.80, P

    Original languageEnglish (US)
    Pages (from-to)771-779
    Number of pages9
    JournalObstetrics and Gynecology
    Volume127
    Issue number4
    DOIs
    StatePublished - Apr 1 2016

    Fingerprint

    Hypertension
    Glucose
    Pregnancy
    Glucose Intolerance
    Observational Studies
    Pregnancy Induced Hypertension
    Gestational Diabetes
    Pre-Eclampsia
    Fasting
    Cohort Studies
    Mothers
    Confidence Intervals
    Blood Pressure
    Lipids
    Serum
    Therapeutics

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    Rice, M. M., Landon, M. B., Varner, M. W., Casey, B. M., Reddy, U. M., Wapner, R. J., ... Vandorsten, J. P. (2016). Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome. Obstetrics and Gynecology, 127(4), 771-779. https://doi.org/10.1097/AOG.0000000000001353

    Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome. / Rice, Madeline Murguia; Landon, Mark B.; Varner, Michael W.; Casey, Brian M.; Reddy, Uma M.; Wapner, Ronald J.; Rouse, Dwight J.; Biggio, Joseph R.; Thorp, John M.; Chien, Edward K.; Saade, George; Peaceman, Alan M.; Blackwell, Sean C.; Vandorsten, J. Peter.

    In: Obstetrics and Gynecology, Vol. 127, No. 4, 01.04.2016, p. 771-779.

    Research output: Contribution to journalArticle

    Rice, MM, Landon, MB, Varner, MW, Casey, BM, Reddy, UM, Wapner, RJ, Rouse, DJ, Biggio, JR, Thorp, JM, Chien, EK, Saade, G, Peaceman, AM, Blackwell, SC & Vandorsten, JP 2016, 'Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome', Obstetrics and Gynecology, vol. 127, no. 4, pp. 771-779. https://doi.org/10.1097/AOG.0000000000001353
    Rice, Madeline Murguia ; Landon, Mark B. ; Varner, Michael W. ; Casey, Brian M. ; Reddy, Uma M. ; Wapner, Ronald J. ; Rouse, Dwight J. ; Biggio, Joseph R. ; Thorp, John M. ; Chien, Edward K. ; Saade, George ; Peaceman, Alan M. ; Blackwell, Sean C. ; Vandorsten, J. Peter. / Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome. In: Obstetrics and Gynecology. 2016 ; Vol. 127, No. 4. pp. 771-779.
    @article{99f670a9bae44bf7bdf1f547e8acea47,
    title = "Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome",
    abstract = "OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47{\%} of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29{\%}) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95{\%} confidence interval [CI] 1.95-4.80, P",
    author = "Rice, {Madeline Murguia} and Landon, {Mark B.} and Varner, {Michael W.} and Casey, {Brian M.} and Reddy, {Uma M.} and Wapner, {Ronald J.} and Rouse, {Dwight J.} and Biggio, {Joseph R.} and Thorp, {John M.} and Chien, {Edward K.} and George Saade and Peaceman, {Alan M.} and Blackwell, {Sean C.} and Vandorsten, {J. Peter}",
    year = "2016",
    month = "4",
    day = "1",
    doi = "10.1097/AOG.0000000000001353",
    language = "English (US)",
    volume = "127",
    pages = "771--779",
    journal = "Obstetrics and Gynecology",
    issn = "0029-7844",
    publisher = "Lippincott Williams and Wilkins",
    number = "4",

    }

    TY - JOUR

    T1 - Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome

    AU - Rice, Madeline Murguia

    AU - Landon, Mark B.

    AU - Varner, Michael W.

    AU - Casey, Brian M.

    AU - Reddy, Uma M.

    AU - Wapner, Ronald J.

    AU - Rouse, Dwight J.

    AU - Biggio, Joseph R.

    AU - Thorp, John M.

    AU - Chien, Edward K.

    AU - Saade, George

    AU - Peaceman, Alan M.

    AU - Blackwell, Sean C.

    AU - Vandorsten, J. Peter

    PY - 2016/4/1

    Y1 - 2016/4/1

    N2 - OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47% of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29%) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95% confidence interval [CI] 1.95-4.80, P

    AB - OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47% of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29%) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95% confidence interval [CI] 1.95-4.80, P

    UR - http://www.scopus.com/inward/record.url?scp=84960158165&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84960158165&partnerID=8YFLogxK

    U2 - 10.1097/AOG.0000000000001353

    DO - 10.1097/AOG.0000000000001353

    M3 - Article

    VL - 127

    SP - 771

    EP - 779

    JO - Obstetrics and Gynecology

    JF - Obstetrics and Gynecology

    SN - 0029-7844

    IS - 4

    ER -