Pregnancy in bone marrow failure syndromes: Diamond-Blackfan anaemia and Shwachman-Diamond syndrome

Blanche P. Alter, Manjusha Kumar, Lillian L. Lockhart, Philippa G. Sprinz, Thomas F. Rowe

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Pregnancy in bone marrow failure syndromes has risk to mother and fetus. There are fewer than 30 reports of cases with Diamond-Blackfan anaemia (DBA), and none with Shwachman-Diamond syndrome (SD). We report two DBA and one SD cases. One DBA mother received transfusions intra-partum, and the other only post-partum. Both required caesarean sections (C-sections) for failure of labour to progress and severe pre-eclampsia respectively. Both subsequently resumed pre-pregnancy steroid-induced control of anaemia. ~40% of DBA pregnancies required maternal transfusions; 25% delivered by C-section. The SD patient also had Ehlers-Danlos (ED) syndrome and urticaria pigmentosa (UP). Her blood counts were adequate until week 38, when the platelet count dropped and a C-section was performed. Pregnancy management in marrow failure disorders requires obstetricians with expertise in high-risk pregnancies, and haematologists with experience with marrow failure syndromes.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalBritish Journal of Haematology
Issue number1
StatePublished - 1999


  • Diamond-Blackfan anaemia
  • Pregnancy
  • Shwachman-Diamond syndrome
  • Steroids
  • Transfusion

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Pregnancy in bone marrow failure syndromes: Diamond-Blackfan anaemia and Shwachman-Diamond syndrome'. Together they form a unique fingerprint.

Cite this