Prenatal alcohol exposure alters the development of sympathetic synaptic components and of nerve growth factor receptor expression selectivity in lymphoid organs

Z. Gottesfeld, B. Morgan, J. R. Perez-Polo

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Exposure to alcohol in utero has been associated with long-term immune deficits. In addition, adult mice exposed to alcohol prenatally display altered noradrenergic synaptic transmission selectively in lymphoid organs. This is consistent with the hypothesis that sympathetic neurons play an important role in immunomodulation. The development and maintenance of sympathetic neurons are critically dependent on nerve growth factor (NGF). Furthermore, NGF has been shown to modulate immune responses and NGF receptor expression has been localized to lymphoid organs. The present work examined the effects of prenatal alcohol exposure on the development and maturation of pre- and postsynaptic sympathetic components, including norepinephrine and β-adrenoceptors, respectively, as well as the early expression of NGF receptors in lymphoid and other organs of the C57BL/6 mouse. Infant mice that were exposed to alcohol in utero displayed reduced levels of norepinephrine and β-adrenoceptor density, as well as increased NGF receptor expression in the thymus and spleen, but not the heart. These selective changes may account, in part, for the persistent immune incompetence characteristic of fetal alcohol syndrome.

Original languageEnglish (US)
Pages (from-to)308-316
Number of pages9
JournalJournal of Neuroscience Research
Volume26
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Nerve Growth Factor Receptor
Alcohols
Nerve Growth Factor
Adrenergic Receptors
Norepinephrine
Nerve Growth Factor Receptors
Fetal Alcohol Spectrum Disorders
Neurons
Immunomodulation
Inbred C57BL Mouse
Synaptic Transmission
Thymus Gland
Spleen
Maintenance

Keywords

  • β-adrenoceptor
  • immunomodulation
  • norepinephrine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prenatal alcohol exposure alters the development of sympathetic synaptic components and of nerve growth factor receptor expression selectivity in lymphoid organs. / Gottesfeld, Z.; Morgan, B.; Perez-Polo, J. R.

In: Journal of Neuroscience Research, Vol. 26, No. 3, 1990, p. 308-316.

Research output: Contribution to journalArticle

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