Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow

Jeffrey W. Milsom, Anthony Senagore, Richard K. Walshaw, Ulreh V. Mostosky, Ping Wang, Wendy Johnson, Irshad H. Chaudry

Research output: Contribution to journalArticle

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Abstract

Preoperative external beam radiation therapy (RT) is an increasingly popular form of adjunct therapy for rectal cancer; however, little is known about its effects on healing of colorectal anastomoses. We serially evaluated colorectal anastomotic healing following moderate dose RT. Twenty-four adult female pigs were administered 4250 centiGrays (cGy) of external beam pelvic RT over 4 weeks followed by rectosigmoid resection with handsewn or circular stapled anastomosis. Groups of animals were then sacrificed at 5, 11, 60, and 120 days postoperatively. A control group (N = 24) was studied similarly but not irradiated. Perianastomotic blood flow was measured using laser doppler velocimetry at each time interval. Nonirradiated anastomoses demonstrated significantly higher blood flows compared to irradiated anastomotic segments at each study interval. In addition, early (Days 5 and 11) postoperative gross inflammatory scores and microscopic inflammatory score (all intervals) were significantly higher for irradiated animals. Anastomotic complications were more frequent in irradiated animals ( 7 24) vs controls ( 2 24, P <0.05). These results indicate that a preoperative dose of 4250 cGy results in an early and persistent decrease in colorectal mural blood flow independent of anastomotic technique. This is the first experimental study which attempts to quantitate the effects of preoperative pelvic radiation therapy on anastomotic blood flow.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalJournal of Surgical Research
Volume53
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

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Radiotherapy
Laser-Doppler Flowmetry
Rectal Neoplasms
Swine
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Milsom, J. W., Senagore, A., Walshaw, R. K., Mostosky, U. V., Wang, P., Johnson, W., & Chaudry, I. H. (1992). Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow. Journal of Surgical Research, 53(5), 464-469. https://doi.org/10.1016/0022-4804(92)90091-D

Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow. / Milsom, Jeffrey W.; Senagore, Anthony; Walshaw, Richard K.; Mostosky, Ulreh V.; Wang, Ping; Johnson, Wendy; Chaudry, Irshad H.

In: Journal of Surgical Research, Vol. 53, No. 5, 1992, p. 464-469.

Research output: Contribution to journalArticle

Milsom, JW, Senagore, A, Walshaw, RK, Mostosky, UV, Wang, P, Johnson, W & Chaudry, IH 1992, 'Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow', Journal of Surgical Research, vol. 53, no. 5, pp. 464-469. https://doi.org/10.1016/0022-4804(92)90091-D
Milsom, Jeffrey W. ; Senagore, Anthony ; Walshaw, Richard K. ; Mostosky, Ulreh V. ; Wang, Ping ; Johnson, Wendy ; Chaudry, Irshad H. / Preoperative radiation therapy produces an early and persistent reduction in colorectal anastomotic blood flow. In: Journal of Surgical Research. 1992 ; Vol. 53, No. 5. pp. 464-469.
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