Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living with HIV

Priyesh Agrawal, Leila B. Giron, Shalini Singh, Nel Jason Haw, Aaron R. Goldman, Mohamed Elkaeid, Bernard MacAtangay, Frank J. Palella, Maria L. Alcaide, Caitlin A. Moran, Seble G. Kassaye, Nathan Erdmann, Kara W. Chew, Michelle Floris-Moore, Aruna Chandran, Michael H. Augenbraun, Anjali Sharma, Clovis Palmer, Alan L. Landay, Michael J. PelusoAli Keshavarzian, Todd T. Brown, Phyllis C. Tien, Mohamed Abdel-Mohsen

Research output: Contribution to journalArticlepeer-review

Abstract

Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long COVID. However, whether preexisting HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing prepandemic samples from PLWH with documented postinfection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.

Original languageEnglish (US)
Pages (from-to)912-918
Number of pages7
JournalJournal of Infectious Diseases
Volume230
Issue number4
DOIs
StatePublished - Oct 15 2024
Externally publishedYes

Keywords

  • COVID-19
  • HIV
  • long COVID
  • metabolites
  • tryptophan

ASJC Scopus subject areas

  • General Medicine

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