Abstract
Host metabolic dysregulation, especially in tryptophan metabolism, is intricately linked to coronavirus disease 2019 (COVID-19) severity and its postacute sequelae (long COVID). People living with human immunodeficiency virus (HIV; PLWH) experience similar metabolic dysregulation and face an increased risk of developing long COVID. However, whether preexisting HIV-associated metabolic dysregulations contribute in predisposing PLWH to severe COVID-19 outcomes remains underexplored. Analyzing prepandemic samples from PLWH with documented postinfection outcomes, we found specific metabolic alterations, including increased tryptophan catabolism, predicting an elevated risk of severe COVID-19 and the incidence of long COVID. These alterations warrant further investigation for their potential prognostic and mechanistic significance in determining COVID-19 complications.
Original language | English (US) |
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Pages (from-to) | 912-918 |
Number of pages | 7 |
Journal | Journal of Infectious Diseases |
Volume | 230 |
Issue number | 4 |
DOIs | |
State | Published - Oct 15 2024 |
Externally published | Yes |
Keywords
- COVID-19
- HIV
- long COVID
- metabolites
- tryptophan
ASJC Scopus subject areas
- General Medicine