Preparation and characterization of neurotoxic tau oligomers

Cristian A. Lasagna-Reeves, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, George R. Jackson, Rakez Kayed

Research output: Contribution to journalArticlepeer-review

208 Scopus citations

Abstract

Tau aggregation is a pathological hallmark of Alzheimer's disease, Parkinson's disease, and many other neurodegenerative disorders known as tauopathies. Tau aggregates take on many forms, and their formation is a multistage process with intermediate stages. Recently, tau oligomers have emerged as the pathogenic species in tauopathies and a possible mediator of amyloid-β toxicity in Alzheimer's disease. Here, we use a novel, physiologically relevant method (oligomer cross-seeding) to prepare homogeneous populations of tau oligomers and characterize these oligomers in vitro. We show that both Aβ and α-synuclein oligomers induce tau aggregation and the formation of β-sheet-rich neurotoxic tau oligomers.

Original languageEnglish (US)
Pages (from-to)10039-10041
Number of pages3
JournalBiochemistry
Volume49
Issue number47
DOIs
StatePublished - Nov 30 2010

ASJC Scopus subject areas

  • Biochemistry

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