Preparation and characterization of neurotoxic tau oligomers

Cristian A. Lasagna-Reeves, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, George R. Jackson, Rakez Kayed

    Research output: Contribution to journalArticlepeer-review

    256 Scopus citations

    Abstract

    Tau aggregation is a pathological hallmark of Alzheimer's disease, Parkinson's disease, and many other neurodegenerative disorders known as tauopathies. Tau aggregates take on many forms, and their formation is a multistage process with intermediate stages. Recently, tau oligomers have emerged as the pathogenic species in tauopathies and a possible mediator of amyloid-β toxicity in Alzheimer's disease. Here, we use a novel, physiologically relevant method (oligomer cross-seeding) to prepare homogeneous populations of tau oligomers and characterize these oligomers in vitro. We show that both Aβ and α-synuclein oligomers induce tau aggregation and the formation of β-sheet-rich neurotoxic tau oligomers.

    Original languageEnglish (US)
    Pages (from-to)10039-10041
    Number of pages3
    JournalBiochemistry
    Volume49
    Issue number47
    DOIs
    StatePublished - Nov 30 2010

    ASJC Scopus subject areas

    • Biochemistry

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