Preparation and characterization of neurotoxic tau oligomers

Cristian A. Lasagna-Reeves, Diana L. Castillo-Carranza, Marcos J. Guerrero-Muñoz, George R. Jackson, Rakez Kayed

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Tau aggregation is a pathological hallmark of Alzheimer's disease, Parkinson's disease, and many other neurodegenerative disorders known as tauopathies. Tau aggregates take on many forms, and their formation is a multistage process with intermediate stages. Recently, tau oligomers have emerged as the pathogenic species in tauopathies and a possible mediator of amyloid-β toxicity in Alzheimer's disease. Here, we use a novel, physiologically relevant method (oligomer cross-seeding) to prepare homogeneous populations of tau oligomers and characterize these oligomers in vitro. We show that both Aβ and α-synuclein oligomers induce tau aggregation and the formation of β-sheet-rich neurotoxic tau oligomers.

Original languageEnglish (US)
Pages (from-to)10039-10041
Number of pages3
JournalBiochemistry
Volume49
Issue number47
DOIs
StatePublished - Nov 30 2010

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Tauopathies
Oligomers
Alzheimer Disease
Synucleins
Amyloid
Neurodegenerative Diseases
Parkinson Disease
Agglomeration
Population
Toxicity
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry

Cite this

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Jackson, G. R., & Kayed, R. (2010). Preparation and characterization of neurotoxic tau oligomers. Biochemistry, 49(47), 10039-10041. https://doi.org/10.1021/bi1016233

Preparation and characterization of neurotoxic tau oligomers. / Lasagna-Reeves, Cristian A.; Castillo-Carranza, Diana L.; Guerrero-Muñoz, Marcos J.; Jackson, George R.; Kayed, Rakez.

In: Biochemistry, Vol. 49, No. 47, 30.11.2010, p. 10039-10041.

Research output: Contribution to journalArticle

Lasagna-Reeves, CA, Castillo-Carranza, DL, Guerrero-Muñoz, MJ, Jackson, GR & Kayed, R 2010, 'Preparation and characterization of neurotoxic tau oligomers', Biochemistry, vol. 49, no. 47, pp. 10039-10041. https://doi.org/10.1021/bi1016233
Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muñoz MJ, Jackson GR, Kayed R. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. 2010 Nov 30;49(47):10039-10041. https://doi.org/10.1021/bi1016233
Lasagna-Reeves, Cristian A. ; Castillo-Carranza, Diana L. ; Guerrero-Muñoz, Marcos J. ; Jackson, George R. ; Kayed, Rakez. / Preparation and characterization of neurotoxic tau oligomers. In: Biochemistry. 2010 ; Vol. 49, No. 47. pp. 10039-10041.
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