Preparation and characterization of tau oligomer strains

Urmi Sengupta, Mariana Carretero-Murillo, Rakez Kayed

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations


An increasing number of studies have demonstrated the existence of multiple conformational entities of tau, as have been observed for prion protein. We have developed and optimized techniques to isolate and study oligomeric tau strains both in vitro and ex vivo. Moreover, we have modified protocols that demonstrate the seeding properties of oligomeric tau strains that are capable of propagating in vivo. These methods and protocols are explained in this chapter.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages34
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • In vitro tau seeding
  • In vivo tau propagation
  • Tau oligomer isolation
  • Tau oligomeric strains

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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